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Background: The purpose of this prospective study was to evaluate if a recently proposed score system based on six preoperative parameters [history of colic pain and/or jaundice, dyspepsia, cholecystitis, ultrasound (US), evidence of common bile duct stones (CBDS), number and size of gallbladder stones at US, level of serum glutamic oxalacetic transaminase(More)
8508 Background: RAF265 is an oral small molecule inhibitor of mutant (mut) BRAFV600E(EC50= 0.14µM) and VEGFR2 (EC50 = 0.19µM). It displays dose dependent inhibition of tumor growth and regression in mut BRAFV600Etumor xenografts, including primary human melanoma models. METHODS This is a FIH, dose escalation study to identify the maximum tolerated dose(More)
HEADINGS Gastroplasty. Diabetes mellitus. morbid obesity. ABSTRACT Background Diabetes mellitus type 2 is not infrequently associated with obesity and can be prevented, improved and even reversed with the different types of bariatric operations. Aim To compare serum glucose levels on pre and postoperative periods in patients undergoing gastroplasty with(More)
8548 Background: Melanoma is a common cause of cerebral metastases, and indicates a poor prognosis. The BRAF inhibitor vemurafenib (V; RG7204, PLX4032) has shown dramatic activity in Phase I and II studies in metastatic melanoma harboring V600-mutated BRAF. These studies excluded patients with active brain metastasis. The activity of V for brain metastases(More)
In this article, we report two cases of gallbladder agenesis that were incorrectly diagnosed as cholelithiasis on preoperative sonography. In the first case, the diagnosis was made by laparoscopic surgery and confirmed by postoperative CT scan. The second case was confirmed by laparoscopic abdominal examination and by laparoscopic sonography. Both patients(More)
The incidence of abdominal pain in patients with systemic lupus erythematosus (SLE) is very high. Most patients do not require surgical treatment (serositis). Some cases such as appendicitis, perforated ulcer, cholecystitis or, rarely, intestinal infarction are surgical. Differential diagnosis is difficult, partly because noninvasive examinations do not(More)
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