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Five investigators familiar with gastric ulcer disease in horses met to establish a scoring system that could be utilised in future studies. Slides of gastric lesions were viewed and discussed and a scoring system established that required the nonglandular and glandular portions of the stomach to be graded separately. Each portion of the stomach (glandular(More)
Drug-induced oesophageal lesions have attracted increasing attention during the past few years. A test model is presented for assessing irritative or ulcerogenic effects of potential drugs on the oesophagus. In this model the pig oesophagus is used, as it is more similar to the human oesophagus than models used in other techniques that have been suggested.(More)
In medical research there is often a need for cerebrospinal fluid (CSF) collection from conscious animals. A number of models have been published, but long-term use is often limited by factors such as damage to implant or loss of patency. When part of an implant is exteriorized, group housing is often not possible; even when singly housed, the instrumented(More)
A conventional cat breeding colony with 70 queens (female cats) was studied during a 4 year period 1979-1982. During that time the fat content in the diet was increased from 15% to 27% of dry matter. An increase in the number of kittens per litter (from 4.5 to 5.5) and in the annual number of litters per queen (from 1.4 to 2.3) was found. In addition, the(More)
Beagle dogs with catheters chronically implanted into the lateral cerebral ventricle were used to study the distribution of atenolol and metoprolol between the cerebrospinal fluid (CSF) and blood plasma over a 24-hr period during long term treatment. The concentration of atenolol declined more slowly in CSF than in blood plasma and the CSF/plasma ratio of(More)
The metabolic disposition of [14C]omeprazole was studied in dogs, rats, and mice after the administration of pharmacologically active, single oral doses of drug in buffer solutions (pH 9). Averages of 38% (dogs), 43% (rats), and 55% (mice) of the radiolabeled doses were excreted in the urine in 72 hr. Most of the remaining dose was recovered in the feces.(More)
The ulcerogenic effect of five different salts of alprenolol were tested against placebo in a porcine oesophageal test model. The salts with high water solubility, such as the hydrochloride and the fumarate, gave rise to the highest plasma concentrations of alprenolol and evoked serious oesophageal lesions, while the salts with low solubility-the benzoate,(More)
The oesophago-irritant potential of terodiline hydrochloride 25 mg tablets was evaluated by use of one acute and two recovery animals models, each documented to be sensitive for predicting local irritant and/or ulcerogenic effects of drugs on the human oesophageal mucosa. Both uncoated and coated terodiline hydrochloride tablets produced slight to moderate(More)
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