S. G. Dzugkoev

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Functional state of the kidneys, severity of metabolic disturbances, intensity of LPO, and activity of the antioxidant system in 30 patients (18-36 years old) with type 1 diabetes mellitus and diabetic nephropathy of different compensation were studied before and after standard therapy or combination treatment with coenzyme Q10. Similar parameters were(More)
Experimental diabetes mellitus was associated with the development of oxidative stress and a decrease in blood concentration of total nitric oxide (NO) metabolites. Administration of L-arginine induced positive changes in the LPO–antioxidant enzyme system and elevated NO concentration in blood serum, whereas L-NAME, inhibitor of eNOS (NOS-III) increased LPO(More)
The performed studies provided new evidence for biological variability in clinically important analytes, estimated a possible association of the metabolic features and the conservative genetic attribute--the ABO blood group. Certain features in the levels of protein, carbohydrate, lipid, and mineral metabolic parameters were revealed in relation to various(More)
Hydrogen peroxide has been found to have a distorting effect on the quality of determination of the serological markers of hepatitis B and C, transglutaminase antibodies: an increase in the percent of false higher (anti-HBsAg, HBeAg, anti-HCV) and false lower (anti-HBeAg) values, and on the results of PCR-based diagnosis (PCR inhibition that was more(More)
On the background of chronic cobalt intoxication in rats develops oxidative stress. This is accompanied by a decrease in the content of total metabolites of nitric oxide in the blood serum. The reasons for lower levels of the vasodilatation factor are the following: a deficiency of L-arginine and the increase in the content of the inhibitor of NOS-3. We(More)
Chronic parenteral administration of cobalt chloride (6 mg/kg) to male rats for 2 weeks or 1 month was accompanied by activation of lipid peroxidation (LPO), a decrease of superoxide dismutase activity and an increase of catalase activity. The membrane toxic action also resulted in a decrease of cortical and medullar Na+,K(+)-ATPase activity of kidneys, and(More)
The influence of L-carnitine and afobazole and their combination with L-arginine on biochemical and histological indices of endothelial dysfunction in rats with cobalt intoxication. The obtained data revealed biochemical markers of endothelial dysfunction. Found that-in rats with cobalt intoxication during treatment occurred inhibition of lipid peroxidation(More)
The study included 39 patients with DM1, symptoms of peripheral diabetic angiopathy and metabolic disorders either compensated, subcompensated or decompensated 20 subjects served as controls. All the patients were given basal therapy with short-acting and intermediate-acting insulins, Some subcompensated patients were treated with hypoglycemic agents in(More)
Oxidizing stress in rats with experimental diabetes mellitis is accompanied by endothelial dysfunction develops. Its biochemical markers are the increase of concentration of blood MDA, the impairments of cell antioxidant depence and a decrease in concentration of total metabolites of NO and expression of endothelial NO-synthetase (e-NOS). Biochemical(More)
Chronic nickel intoxication caused by parenteral nickel chloride administration (0.5 mg/kg of body weight) to Wistar rats led to ROS generation inducing LPO in erythrocyte membranes and homogenates of renal, liver, and myocardial tissue. Superoxide dismutase (SOD) activity was inhibited, while catalase activity and ceruloplasmin concentration increased. LPO(More)
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