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Proline rich polypeptide-1 (PRP-1) consisting of 15 amino acid residues (AGAPEPAEPAQPGVY) is a regulatory hypothalamic peptide possessing neuroprotective, immunoregulatory, hematopoietic, and antimicrobial properties. In order to quantify PRP-1 in rat blood, an enzyme linked immunosorbent assay (ELISA) has been applied using polyclonal antibody raised(More)
A fragment (11–19) of thymosin β4 was found to stimulate phosphodiesterase activity even in the absence of calcium and calmodulin. Half-maximal enzyme activation occurred with 10 nM peptide, and was further increased by phospholipids such as phosphatidylserine. The mechanism of stimulation is an increase in the Vmax of cAMP degradation without a substantial(More)
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