S. Farid Hendi

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The roughness of the protein energy surface poses a significant challenge to search algorithms that seek to obtain a structural characterization of the native state. Recent research seeks to bias search toward near-native conformations through one-dimensional structural profiles of the protein native state. Here we investigate the effectiveness of such(More)
—Protein structure prediction remains a central challenge in computational structural biology. Even at the coarse-grained level of detail, the protein conformational space is vast, and available energy functions contain many false local minima. In order to effectively characterize this space, a conformational search must sample a geometrically-diverse set(More)
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