S. F. Vershinina

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Gemcitabine is known to exert a therapeutic effect on brain tumors despite the limited permeability of the blood-brain barrier (BBB). In our experimental research single intraperitoneal (i.p.) injection of gemcitabine 25 mg/kg provided increase in median survival of mice with intracranially transplanted Ehrlich carcinoma by 41-89% (p < 0.001). In this(More)
A study was made of the formation of cataract in rats at remote times after whole-body and partial X irradiation. The whole-body radiation loses were 5 and 10 Gy (two fractions of 5 Gy at a 30-day interval). Partial exposure of the head and neck, as well as irradiation of chest were performed with doses of 5, 10 (two fractions at a 30-day interval) and 15(More)
A study was made of the effect of gamma- and gamma-neutron-radiation, with neutron energy of 0.9 MeV, on the free amino acid composition and antiprotease activity of blood as well as on the life span of albino mongrel rats. The data obtained indicate that changes in the metabolic pool of blood amino acids and inhibitory capacity of blood with respect to(More)
The paper presents data on the effect of 5-fluorouracil (5-FU)-impregnated Coletex napkins on rats and mice with transplantable subcutaneous tumors of different histological patterns: Pliss lymphosarcoma, Walker carcinosarcoma and Ehrlich carcinoma. Since the napkins showed antitumor activity it is suggested that they might find application in treating a(More)