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Two earlier studies resulted in the design of a phase II trial of 41.8 degrees C (x 60 min) extracorporeal whole body hyperthermia (WBH) with ICE, i.e. ifosfamide (5 g/m2), carboplatin (300 mg/m2), and etoposide given with WBH, as well as, day 2 and 3 post-WBH (100 mg/m2) for adult patients with refractory sarcoma. 12 patients entered this trial; all were(More)
The purpose of this study was to evaluate the pharmacokinetics, biological interactions, and toxicities of ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia (WBH) for 1 h in a pilot clinical study. Nineteen patients with refractory sarcoma or malignant teratoma were treated. To obtain baseline pharmacokinetic data for(More)
STUDY OBJECTIVE To evaluate the profile of molecular hemostatic markers in patients receiving either spinal or balanced general anesthesia for total hip arthroplasty. DESIGN Open, randomized, observational study. SETTING Orthopedic unit and central laboratory of a university hospital. PATIENTS 26 consenting ASA physical status II and III inpatients(More)
We have compared the Doppler against the thermodilution technique for measurement of cardiac output in six patients during aortic surgery. The correlation coefficient between the two methods was between 0.76 and 0.84 during the different periods of the operation. Using the integral nomogram instead of direct calibration, the Doppler system underestimated(More)
The role of urotensin II (U-II)--a vasoactive, mitogenic, and inotropic, peptide--in the pathophysiology of heart failure is controversial. The present study explores the relationship between plasma U-II immunoreactivity (U-IIIR) and hemodynamics in patients with coronary artery disease (CAD). Thirty-six patients with CAD-3 undergoing coronary artery bypass(More)
UNLABELLED Allogeneic blood requirements in cardiac surgery shows a wide variation even for comparable procedures. The aim of the present study was to compare the intraoperative allogeneic blood requirement in defined cardiac operations among 12 cardiac centers in Germany. METHOD A data set with 25 variables concerning the intraoperative course in adult(More)
BACKGROUND The present pilot study was conducted to evaluate the effect of isolated short-term lung perfusion during cardiopulmonary bypass (CPB) on inflammatory response and oxygenation. METHODS A total of 24 patients undergoing elective cardiac surgery with routine CPB were prospectively assigned to three groups. Group I (n = 7), control subjects(More)
BACKGROUND Postoperative bleeding still remains a serious problem in bypass surgery. This study evaluated fibrinolysis and perioperative low-dose antifibrinolytic regimens adjusted to the time course of fibrinolysis. METHODS In a prospective, randomized study of 42 patients undergoing bypass grafting, patients received low-dose aprotinin (group A; n = 14)(More)
An innovative pain management system, namely Epione, is presented here. Epione deals with three main types of pain, i.e., acute pain, chronic pain, and phantom limb pain. In particular, by using facial expression analysis, Epione forms a dynamic pain meter, which then triggers biofeedback and augmented reality-based destruction scenarios, in an effort to(More)
—Post-amputation sensation often translates to the feeling of severe pain in the missing limb, referred to as phantom limb pain (PLP). A clear and rational treatment regimen is difficult to establish, as long as the underlying pathophysiology is not fully known. In this work, an innovative PLP management system is presented, as a module of an holistic(More)