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OBJECTIVE Bladder cancer (BC) has the highest lifetime treatment costs per patient of all cancers. The high recurrence rate and ongoing invasive monitoring requirement are the key contributors to the economic and human toll of this disease. The purpose of this paper was to utilize the recent literature to identify opportunities for improving the benefits(More)
BACKGROUND Organic cation transporters (OCTs) determine not only physiological processes but are also involved in the cellular uptake of anticancer agents. Based on microarray analyses in hepatocellular carcinoma (HCC), SLC22A1/OCT1 mRNA seems to be downregulated, but systematic protein expression data are currently missing. Moreover, the underlying(More)
Electronic spreadsheets have made a major contribution to financial analysis and problem solving processes. Decisions made using these tools often involve substantive consequences for the organizations. However, academic literature reveals that experienced professionals and students make many errors when developing spreadsheets. Practitioners recognize the(More)
Management of prostate cancer is recognized as one of the most important medical problems. Latest findings concerning the role of circulating (CTC) and disseminated tumor cells (DTC) have provided new insights into the biology of metastasis with important implications for the clinical management of prostate cancer patients. Most of the established methods(More)
In renal cell carcinoma (RCC), single members of the Wnt/β-catenin signaling cascade were recently identified to contribute to cancer progression. However, the role of Wnt1, one of the key ligands in β-catenin regulation, is currently unknown in RCC. Therefore, alterations of the Wnt1/β-catenin axis in clear cell RCC (ccRCC) were examined with regard to(More)
It is well documented that electronic spreadsheet models utilized in many professions to enhance decision making frequently contain errors that have negative effects on the ultimate quality of decisions. Limited research has been published that systematically identifies potential reasons for the causes of these errors, and what procedures can be taken to(More)