S. E. Kolbasov

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AIM To perform preclinical assessment of new live monovalent vaccine Influvir against pandemic influenza virus A/H1N1 [strainA/17/California/2009/38 (H1N1)]. MATERIALS AND METHODS Preclinical studies of acute toxicity and effect of Influvir vaccine on systems and organs of laboratory animals (rats and outbred white mice) was performed according to modern(More)
Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its(More)
Acute oral chlorophos poisoning of laboratory animals was shown to result in a decrease of the pulmonary surfactant system according to the severity of intoxication. Alupent in combination with atropine and dipyroxime prevented the disturbances of the system.
strated that transcranial electrostimulation activates the endorphin structures of the brain to restore functional activity and facilitate the repair of damaged gastrointestinal epithelial cells and hepatocytes [1, 4]. Given that there is an ontogenetic relationship between the gastroduodenal epithelium, its derivatives (hepatocytes), and pancreatic(More)
Positive effects of angiogen, a preparation containing succinic and acetylsalicylic acids, on ECG, blood clotting, and lipid metabolism were demonstrated on animals with experimental cardiovascular disease induced by repeated injections of norepinephrine.
Clinical data on the surfactant system of the lungs during poisoning with neurotoxic toxins are presented and approaches to drug correction of lung system disorders in severe intoxication with neurotoxic agents are offered.
AIM To perform preclinical study of subunit monovalent adsorbed inactivated influenza vaccine "PANDEFLU" [strains A/California/7/2009 (HIN1)v]. MATERIALS AND METHODS Preclinical study of acute toxicity on experimental animals (assessment of vaccine's toxic effects on organs and body systems; pathomorphologic study of organs and tissues after(More)
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