S E Frederick

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BACKGROUND A history of major depressive disorder (MDD) predicts failure to quit smoking. We determined the effect of nortriptyline hydrochloride and cognitive-behavioral therapy on smoking treatment outcome in smokers with a history of MDD. The study also addressed the effects of diagnosis and treatment condition on dysphoria after quitting smoking and the(More)
A confluence of evidence indicates that alterations in hypothalamic-pituitary-adrenal regulation can have profound effects on the symptom picture of psychiatric illnesses and that therapeutic interventions directly targeted at corticosteroid metabolism may have clinical benefit. This paper reviews the varying lines of inference that support such a(More)
We present dynamically reconfigurable photonic crystal nanobeam cavities, operating at ~1550 nm, that can be continuously and reversibly tuned over a 9.5 nm wavelength range. The devices are formed by two coupled nanobeam cavities, and the tuning is achieved by varying the lateral gap between the nanobeams. An electrostatic force, obtained by applying bias(More)
We describe a photonic crystal nanocavity with multiple spatially overlapping resonances that can serve as a platform for nonlinear frequency conversion. We show nonlinear characterization of structures with two resonances nearly degenerate in frequency. We also demonstrate structures with resonances separated by up to 523 nm. ultracompact buried(More)
Optical fiber tapers are used to collect photoluminescence emission at ~1.5 µm from photonic crystal cavities fabricated in erbium doped silicon nitride on silicon. In the experiment, photoluminescence collection via one arm of the fiber taper is enhanced 2.5 times relative to free space collection, corresponding to a net collection efficiency of 4%.(More)
  • Ranojoy Bose, Jie Gao, James F Mcmillan, Alex D Williams, Chee Wei Wong, H Mabuchi +217 others
  • 2009
We present evidence of cavity quantum electrodynamics from a sparse density of strongly quantum-confined Pb-chalcogenide nanocrystals (between 1 and 10) approaching single-dot levels on moderately high-Q mesoscopic silicon optical cavities. Operating at important near-infrared (1500-nm) wavelengths, large enhancements are observed from devices and strong(More)
We demonstrate up to 30 nm tuning of gallium phosphide photonic crystal cavities resonances at ~1.5 µm using a tapered optical fiber. The tuning is achieved through a combination of near-field perturbations and mechanical deformation of the membrane, both induced by the fiber probe. By exploiting this effect, we show fiber-coupled second harmonic generation(More)
Difference-frequency generation with quantum-limited efficiency in triply-resonant nonlinear cavities. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits(More)
Recent studies have demonstrated the presence of fibres immunoreactive for somatostatin-28 (SS-28), which originate in the brainstem and selectively innervate the magnocellular oxytocin (OT) cells of the supraoptic nucleus. The potential physiological relevance of this pathway was investigated in the present study by measuring plasma OT levels in response(More)
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