S. E. Antipas

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The plasma clearance rate of heat denatured human serum albumin (DHAI-125, 5 mg/kg body weight) was studied in 20 children with homozygous-β-thalassemia before and 7–10 days after blood transfusion. A significant increase of the DHAI-125 clearance rate (P<0.02) was found 7–10 days after blood transfusion while the spleen presented its minimum size. This(More)
Denatured radioiodinated human serum albumin (DHA) clearance studies at a dose of 1 mg/kg body wt., were carried out in 16 thalassemic children, prior to and 7–10 days following blood transfusion, to investigate changes of the effective RES blood flow which might accompany the posttransfusion spleen size diminution. A statistically significant increase(More)
The parameters of 51Cr labelled red cell survival curves were calculated in 33 patients with homozygous β-thalassaemia, 8 with sickle-cell anaemia and 3 with s-β-thalassaemia, using a non-linear weighted least squares analysis computer program. In thalassaemic children the calculated parameters denote that the shortening of the mean cell life is due to(More)
A new theoretical five-compartmental model (5CM) was developed for analysis of the clearance of heat-damaged erythroctes (HDE) labelled with chromium 51. Besides the HDE-spleen interaction, this new model also takes into account the interaction between extrasplenic reticuloendothelial (RES) sites and HDE, i.e. the hepatic clearance of fragmented(More)
The weighted least squares analysis (WLS) was compared with the commonly used least squares analysis in the fitting of radioactivity data to an exponential equation. The results show that the two methods present the same accuracy in estimating the parameters of exponential functions, while the WLS analysis offers a much higher reliability, permitting a(More)
The activity of reticuloendothelial system (RES) was estimated in 19 patients with β-thalassemia major, 20±4 years old, who had undergone successful splenectomy 6±5 years previously. The kinetics of 125I denatured human serum albumin in low and large doses was applied for this purpose and the parameters derived (effective RES blood flow-ERBF- and maximum(More)
The activity of the remaining reticuloendothelial system (RES) and the function of the splenic remnants was estimated in 5 thalassemic patients who had undergone successful partial splenic embolization (PSE) 6 yr previously. The kinetics of 125I-heat-denatured human albumin as well as that of 51Cr-heat-damaged homologous red blood cells were applied for(More)
The effect of blood transfusion on 51Cr-red blood cells surface-counting patterns was studied in 22 patients with homozygous beta-thalassaemia being transfused during erythrocyte survival study. Surface-counting patterns of 15 thalassaemics who had not been submitted to blood transfusion during the erythrocyte survival study were served as controls. In 17(More)
Experience with 250 cases of hypospadias over the 6-year period 1986–1992 at the Athen's Childrens Hospital Aghia Sophia is presented. A successful outcome was seen in 87%, 13% developed complications, most of which were urethral fistulae. The operative techniques and methods of treating the fistulae are described. Patients received treatment in the(More)