S. D. Trzhetsinskii

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Several repor ts of studies on the role of neuropeptides in regulating the endocrine functions of the pancreas have been published [5, 6, 10, 18]. Hypothalamic cholecystokinin (CCK) has been shown to take part in the morphogenesis of the pancreas during the embryonic [11] and early postnatal periods [8] and subsequently to affect the state of hypothalamic(More)
The native sum of valepotriates isolated from Val. alliariifolia Adams which was named valiracyl is an agent of low toxicity and exerts a pronounced neurotropic effect. Valiracyl suppresses the orientation reflex of animals in an "open field", decreases a spontaneous and caffeine-stimulated motor activity, potentiates and prolongs the action of(More)
i. ~ T. J. Mabry, K. R. Markham, and M. B. Thomas, The Scie~ntific Identification of Plavonoids, Springer, New York (1970), po 271~ 2. N. Cheronis, llicro and Semimicromethods (Volo 6 of Technique of Organic Chemistry), Interscience, New York (1954). 3. M. Jay and Jo F. Gonnet, Phytochem., 12, 953 (1973)~ 4o N. Fo Komissarenko, A. N. Derkach, i~ P.(More)
7, 8. 9. A. I. Yakovlev, S. I. Budantseva, et al., Proceedings of the VIIth All-Union Conference on the Chemistry and Biochemistry of Carbohydratea [in Russian], Pushchino (1982). p. 77. Z. L. Kertest, The Pectin Substances, Interscience, New York (1951), p. 128. F. Khenglein, in: Biochemical Methods of Plant Analysis [in Russian], Moscow (1960), p. 290. H.(More)
Intracerebroventricular (1.5 pM) and intraperitoneal (1.0 nM) injections of bombesin for 10 days enhance insulin synthesis and secretion and reduce glycemia in rats with streptozotocin-induced diabetes mellitus as compared with nontreated diabetic rats. In intact rats insulin synthesis in β-cells is stimulated only by intracerebroventricular injections of(More)
In the epigeal part of Yaleriana fasciculata Worosch. et Gorovoi [i], collected on the rocky banks of the R. Selimzhi in the environs of the village of Ekimchan, Amur province, in July 1981, about 20 phenolic compounds consisting of cinnamic acids and flavonoid glycosides have been detected by two-dimensional PC in the solvent systems, I) BAW (4:1:2) (first(More)
The investigation was performed in 96 Wistar rats. Diabetes mellitus was induced by single injection of 50 mg/kg of streptozotocin. Cholecystokinin (CCK) synthesizing neurons were identified in hypothalamic structures using indirect immunofluorescence. In latent period of diabetes (2 wks) number of CCK--immunopositive neurons increases, especially in(More)
Species of the genus Valeriana L. are arousing interest as sources of valepotriates, which are acylated iridoids possessing a sedative action [i]. The valepotriates from the epigeal organs of V. alliariifolia Adams [2] collected in July, 1982, in the Gomis-Mta region of the Adzhar ASSR were extracted with methylene chloride in a Soxhlet apparatus at a(More)