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Anthracnose is an economically important disease of grapes in India. Apart from Elsinoe ampelina, Colletotrichum gloeosporioides and C. acutatum are also implicated in this disease in India. To resolve the etiology of the disease, cultural, morphological and molecular methods of identification were employed. Three hundred and eighty two isolates(More)
Survey conducted during 2010–2011 in the vineyards of Nashik and Pune regions of India revealed the association of an Ampelovirus antigenically related to Grapevine leafroll-associated virus 3 (GLRaV-3) with seven cultivars of grapevine. Upon sequencing of the coat protein (CP) and partial heat shock protein 70 homologue (HSP70h) genes of GLRaV-3 present in(More)
The yeast has important role in fermentation of wine grapes and wine quality. The fermentation of wine grapes affect by efficiency of particular yeast strain, sugar content, pH, available temperature, etc. To evaluate the efficiency of yeast strains (Premier Cuvee, RS-1, RS-2, RS-3 and natural), present study was conducted on two wine grape varieties viz.;(More)
The biodegradation of profenofos, an organophosphorus insecticide, by four Bacillus subtilis strains, namely, DR-39, CS-126, TL-171, and TS-204, isolated from grapevines or grape rhizosphere was studied in liquid culture, on grape berries, and in vineyard soil. Each of the four B. subtilis strains enhanced the degradation of profenofos in all three(More)
Disease management in vineyards with fungicides sometimes results in undesirable residue accumulations in grapes at harvest. Bioaugmentation of the grape fructosphere can be a useful approach for enhancing the degradation rate and reducing the residues to safe levels. This paper reports the in vitro and in vivo biodegradation of three triazole fungicides(More)
Post graduate department of pharmaceutical chemistry. ABSTRACT Even today, new drugs are usually not discovered by rational drug design although this would be the dream of the medically oriented chemist. On an average, it is still necessary to synthesize and test about 10000 new compounds in order to discover a new active substance. In many cases, the(More)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental importance in the brain. They are responsible for the majority of fast excitatory synaptic transmission, and their overactivation is potently excitotoxic. Recent findings have implicated AMPA receptors in synapse formation and stabilization, and regulation of functional(More)
Food safety is a global concern due to the increased use of pesticides in agriculture. In grapes, carbendazim is one of the frequently detected fungicides. However, it is amenable to biodegradation. In this study, we aimed to assess the degradation of carbendazim by four Bacillus subtilis strains, which had earlier shown potential for biocontrol of grape(More)
The search for newer cytotoxic agents has taken many paths in the recent years and in fact some of these efforts led to the discovery of some potent cytotoxic agents. Though the vast number of targets of tumor progression has been identified recently, kinases remained key targets in drug design. It is well established that inhibition of JNK1, a(More)