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BACKGROUND We investigated the viability of psychometrically robust executive function measures as markers for premanifest Huntington's disease (HD). METHODS Fifteen premanifest HD subjects and 42 controls were compared on the NIH EXAMINER executive function battery. This battery yields an overall executive composite score, plus working memory, cognitive(More)
OBJECTIVE To characterize the cognitive and neuropsychiatric symptoms of patients with behavioral variant frontotemporal dementia (bvFTD) over the natural course of the disease. METHODS We examined the initial and subsequent neuropsychological test performance and neuropsychiatric symptoms in a large cohort of patients with bvFTD (n = 204) across(More)
BACKGROUND Cognitive deficits are presumed to be the primary driver of functional impairment in Alzheimer's disease (AD); however, functional impairment is likely multifactorially determined. OBJECTIVE Our objective was to determine the relative contribution of neuropsychiatric symptoms in predicting ratings of functional status. METHODS A total of 223(More)
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