Cyclosporine (CyA) has proved to induce cell apoptosis on cultured proximal tubule cells. However, there is no much data about the in vivo functional consequences of this injury or the long time observed CyA-induced renal vasoconstriction.
MATERIAL AND METHODS
In a swine model of subacute CyA nephrotoxicity (10 mg/ Kg. dx 15 days), we… (More)