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OBJECTIVE Neuronal networks with a so-called "small-world" topography (characterized by strong clustering in combination with short path lengths) are known to facilitate synchronization, and possibly seizure generation. We tested the hypothesis that real functional brain networks during seizures display small-world features, using intracerebral recordings(More)
Considering the brain as a complex network of interacting dynamical systems offers new insights into higher level brain processes such as memory, planning, and abstract reasoning as well as various types of brain pathophysiology. This viewpoint provides the opportunity to apply new insights in network sciences, such as the discovery of small world and scale(More)
Previous studies with intracranial recordings suggested that a more random spatial structure of functional brain networks could be related to seizure generation. Here, we studied whether similar network changes in weighted and unweighted networks can be found in generalized absence seizures recorded with surface EEG. We retrospectively selected EEG(More)
PURPOSE Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point. As epilepsy surgery is considered a last resort by most physicians, a long history of epileptic seizures prior to surgery is not uncommon. Little is known about the effects of ongoing TLE on neural functioning. A better understanding of these(More)
OBJECTIVE To assess the inter-observer agreement of the electroencephalogram (EEG) diagnosis of (non-convulsive) seizures in comatose patients. DESIGN/SETTING/PATIENTS Nine clinicians with different levels of experience in clinical neurophysiology were asked to evaluate in a strictly controlled way 90 epochs (10s each) of 30 EEG's of 23 comatose patients(More)
We investigated the relationship between structural network properties and both synchronization strength and functional characteristics in a combined neural mass and graph theoretical model of the electroencephalogram (EEG). Thirty-two neural mass models (NMMs), each representing the lump activity of reasonably large groups of interacting excitatory and(More)
We present a 36-year-old Dutch woman who suffered from a progressive form of cerebellar ataxia since school age. In her childhood she was diagnosed with Friedreich's ataxia. Genetic analysis of the frataxin gene at 34 years of age, however, had revealed no abnormal GAA triplet expansion. We identified two point mutations in the alpha-tocopherol transport(More)
The EEG is an accessible tool for detecting encephalopathy, which usually manifests as delirium and sometimes as coma. Several disturbances have been described in the EEG of patients with encephalopathy, including diffuse slowing and periodic discharges. The pathophysiology of these EEG alterations, however, is poorly understood. This article shows that(More)
INTRODUCTION Continuous EEG (cEEG) is of great interest in view of the reported high prevalence of non-convulsive seizures on intensive care units (ICUs). Here, we describe our experiences applying a seizure warning system using cEEG monitoring. METHODS Fifty comatose ICU patients were included prospectively and monitored. Twenty-eight patients had(More)
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