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The morphology and synaptic associations of dopaminergic axons in the n. caudate-putamen (neostriatum) of the adult rat brain are examined. Identification of dopaminergic axons is based upon the electron microscopic immunocytochemical localization of the catecholamine synthesizing enzyme, tyrosine hydroxylase. Immunoreactivity for the enzyme is detected in(More)
The peroxidase-antiperoxidase (PAP) immunocytochemical technique was used to determine the light and electron microscopic localization of antisera directed against either methionine [Met5]-or leucine [Leu5]-enkephalin in the neostriatum of brains from untreated rats. By light microscopy, neuronal perikarya and processes showing enkephalin-like(More)
In fetal rat brain, immunocytochemical localization of tyrosine hydroxylase and methionine (Met5)-enkephalin demonstrates that dopaminergic axons labeled with the biosynthetic enzyme can be detected in th neostriatum prior to the appearance of the peptide in neuronal perikarya. The tyrosine hydroxylase-labeled axon terminals in adult neotriatum may form(More)
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