S. Barros

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Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad applicability. In this report, we develop systemic delivery(More)
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/kg), rats (ED50 < 0.01 mg/kg), and nonhuman primates (over(More)
One of the most significant challenges in the development of clinically viable delivery systems for RNA interference therapeutics is to understand how molecular structures influence delivery efficacy. Here, we have synthesized 1,400 degradable lipidoids and evaluate their transfection ability and structure-function activity. We show that lipidoid(More)
Formulation of short interfering RNA (siRNA) into multicomponent lipid nanoparticles (LNP) is an effective strategy for hepatic delivery and therapeutic gene silencing. This study systematically evaluated the effect of polyethylene glycol (PEG) density on LNP physicochemical properties, innate immune response stimulation, and in vivo efficacy. Increased PEG(More)
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge for RNAi therapeutics is the development of safe delivery vehicles for small interfering RNAs (siRNAs). We(More)
We present high time resolution VLT spectroscopy of SDSS J124058.03−015919.2, a new helium-transferring binary star identified in the Sloan Digital Sky Survey. We measure an orbital period of 37.355 ± 0.002 minutes, confirming the AM CVn nature of the system. From the velocity amplitudes of the accretor and the accretion stream– disc impact, we derive a(More)
  • José A M Demattê, Leonardo Ramirez-Lopez, Rodnei Rizzo, Marcos R Nanni, Peterson R Fiorio, Caio T Fongaro +9 others
  • 2016
There is a consensus about the necessity to achieve a quick soil spatial information with few human resources. Remote/proximal sensing and pedotransference are methods that can be integrated into this approach. On the other hand, there is still a lack of strategies indicating on how to put this in practice, especially in the tropics. Thus, the objective of(More)
  • C Weiß, E Chiaveri, S Girod, V Vlachoudis, O Aberle, S Barros +126 others
  • 2015
At the neutron time-of-flight facility n TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall(More)