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Permeability of the blood-brain barrier is not changed by vasoactive doses of arachidonic acid or prostaglandins in rats.

• Floyd R. Domer, S B Boertje, Jennifer Sampson
• Research communications in chemical pathology and…
• 1985

Charles River, Sprague-Dawley rats of both sexes were anesthetized with pentobarbital sodium, 50 mg/kg i.p. and a jugular vein and femoral artery cannulated. Saline, arachidonic acid (1, 2, 4 or 6… (More)

Blockade of the acetylcholine-and histamine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats by atropine and pyrilamine.

• Floyd R. Domer, S B Boertje, Sharlynn Sweeney
• Research communications in chemical pathology and…
• 1983

We have studied the effects of premedication with either atropine or pyrilamine on the responses of the blood pressure and the permeability of the blood-brain barrier (BBB) in normotensive (WKY) or… (More)

Blockade of histamine-stimulated alterations in cerebrovascular permeability by the H2-receptor antagonist cimetidine.

• S B Boertje, D S LE BEAU, C. Williams
• Neuropharmacology
• 1989

Histamine has been shown previously to cause dose-dependent systemic hypotension and concurrent alterations in the permeability of the blood-brain barrier of rats. The purpose of the present study… (More)

H2-receptors mediate histamine-induced variations in the permeability of the blood-brain barrier of rats.

• S B Boertje, S. Ward, A. Robinson
• Research communications in chemical pathology and…
• 1992

Earlier investigations suggested that histamine H2-receptors mediate alterations in cerebrovascular permeability in mammals. The objective of this study was to observe the effects of the H2-receptor… (More)

Impromidine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.

• S B Boertje, D S LE BEAU, S. Ward
• Research communications in chemical pathology and…
• 1990

Previous studies suggested histamine receptors mediate changes in the cerebrovascular permeability of rats. To test this, we investigated the effects of impromidine, a specific agonist at the… (More)

Histamine- and acetylcholine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.

• Floyd R. Domer, S B Boertje, Eric G. Bing, I Reddix
• Neuropharmacology
• 1983

Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats were given saline, histamine (1.25, 2.5 or 5.0 micrograms/kg) or acetylcholine (1.0 or 2.0 micrograms/kg). Both agents caused a… (More)

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