S. A. Polenov

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Although a large body of evidence shows that pretreatment of brain tissue with creatine protects against anoxic injury in vitro, only a couple of papers have investigated creatine protection in vivo, and they yielded conflicting results. We attempted to clarify how creatine may be protective in an in vivo model of global cerebral ischemia (GCI). We(More)
Experiments were performed on rats anesthetized with urethane and nembutal. Intrathecal administration of a nitric oxide inhibitor L-NAME (60 mg) into the cerebrospinal fluid of the thoracic spinal cord was followed by a 40–45% decrease in tonic activity of efferent fibers of the abdominal aortic nerves. L-NAME reduced a reflex increase in the rate of(More)
Analysis of the literature shows that several dozens of interacting factors and several hundreds of connections between these factors should be taken into account to describe the process of digestion. It is obvious that such a huge body of experimental data can only be systematized using mathematical simulation. Here, we present the first qualitative(More)
In anesthetized cats, blockade of the intermediate chemosensitive area (area "S") of the ventral medulla by means of local cooling to 20-22 degrees C induced drop of arterial blood pressure by 22% as well as of the perfusion pressure in hind-limb skin-muscular and muscular preparations by 24% and 12%, resp. Analogous cooling of the caudal chemosensitive(More)
Pepsinogen secretion in the intraluminally perfused stomach of narcotized rats was induced by electrical stimulation of the vagus nerve or intravenous injection of pentagastrin. Blockade of histamine H2 receptors inhibited pepsinogen production induced by vagal stimulation by 35%, but caused only a 13% decrease in pentagastrin-stimulated pepsinogen(More)
 Phosphocreatine can to some extent compensate for the lack of ATP synthesis that is caused in the brain by deprivation of oxygen or glucose. Treatment of in vitro rat hippocampal slices with creatine increases the neuronal store of phosphocreatine. In this way it increases the resistance of the tissue to anoxic or ischemic damage. In in vitro brain slices(More)