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WHAT IS KNOWN AND OBJECTIVE Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication should be stopped and dose tapering is(More)
The consumption of generic drugs differs widely among European countries, ranging from about 10–15 % (Poland, Hungary, Romania, Czech, Slovakia, Ireland, and Italy) to above 60 % (UK, Germany, or Netherlands) and definitely lower than that registered in USA (about 84 %) [1]. Although the Italian National Health Service (NHS) adopts generic substitution at(More)
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