S. A. Lebedeva

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In vitro study of phagocytosis has shown that in guinea pigs fraction 1 is conducive to the ingestion of Y. pestis by macrophages, to survival and proliferation of Y. pestis cells in these macrophages, as well as to their specific transformation leading to their increased ingestive and bactericidal activity with respect to Y. pestis. In mice the role of(More)
Chronic administration of 50% ethanol in a dose of 8 g/kg produces a toxic effect on functional activity of cardiomyocyte mitochondria, which manifested in decreased rates of respiration and oxidative phosphorylation. Structural GABA analogue Citrocard (phenibut citrate) and reference preparation piracetam in doses of 50 and 200 mg/kg, respectively,(More)
The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of drug action were analyzed, and its safety (abuse potential in the reaction of self-stimulation) was evaluated. Dietressa was not inferior to sibutramine(More)
AIM To characterize species specificity of officially recommended tests for differentiation of Yersiniapestis and Yersinia pseudotuberculosis and propose additional tests allowing for more accurate identification. MATERIALS AND METHODS Natural, laboratory and typical strains oftwo Yersinia species were studied using microbiological, molecular and(More)
92 strains of Yersinia pestis isolated from different natural foci and stored for 3-40 years in the museum of live cultures have been studied. The strains having three typical plasmids, their different combinations, plasmidless strains or the strains carrying nontypical plasmids with the molecular masses 9, 15, 55, 80, 90 and 150 Md were found. The old(More)
The data of literature on the pleiotropic variability of the resistance of Y. pestis mutants to diagnostic phage are presented. The conditions of reversion to the initial phenotype are characterized. The mechanisms of the appearance of such variability of Y. pestis, as well as problems arising in connection with this variability and linked with the(More)
Problems and aspects of the intraspecific differentiation of the plague infectious agent are discussed. Special attention is paid to the necessity of a more precise definition of the taxonomic location of plague agents in view of their genotypic characteristics, selective virulence, and the evolutionary descent of the genus Yersinia.
Yersinia pestis plasmids having inserted Tn-movable elements and determining pesticinogenicity, Ca2+-dependence, production of mice toxin and fraction I have been mobilized for conjugal transfer into Y. pestis, Y. pseudotuberculosis or E. coli cells by plasmid pKA7. Plasmid determinants have been transferred with the frequencies 10-4-10-7 per donor cell.(More)
Traditionally, collection of information from synaptic inputs distributed on dendrites and transmission of this information to the soma of the neuron were believed to be the only functions of these neuron compartments. In recent years, such a viewpoint was revised to a considerable extent due to novel results demonstrating that the dendrites can realize the(More)