S. A. Kryzhanovskii

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We recorded EEG in adult volunteers in the course of perception of smells of plant essential oils under conditions of directed attention. It was found that perception of olfactory information, even in the case of mild intensity of the smells inducing no aversive effects, correlates with noticeable changes in the EEG characteristics mostly typical of the(More)
ω-3 polyunsaturated fatty acids (PUFAs) (alpha-linolenic, eicosapentaenoic, and decosahexaenoic acids) are classified with essential fatty acids and are structural components of the phospholipid bilayer of cell membranes. ω-3 PUFAs incorporated into the phospholipid domain of cell membranes are metabolized to prostaglandins and thromboxanes (PGI 3, PGE 3,(More)
Echocardiography in control narcotized rats (n = 12) revealed that acute single-stage ligation of coronary artery induced a rapid and significant decrease in systolic function of the heart, which attained minimum to postischemic minutes 10-20 and then gradually restored during 60 min after coronary occlusion. Matrix proteinase inhibitor doxycycline (40(More)
The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 μg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alkyl amine derivatives was used as the(More)
Previously, it was demonstrated that many piperazine derivatives possess antiarrhythmic properties [1, 2]. Here we report on the synthesis and antiarrhythmic activity of a series of 2-[(2 -hydroxy-2 -R)-ethyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines (IVa – IVg). The new compounds were synthesized according to the following scheme. In the first step,(More)
Several antihypertensive drugs belonging to the group of ACE inhibitors have been selected for testing their nootropic activity based on a computer-aided prediction of their biological activity spectra using the PASS computer program package. Experiments were conducted on mice by the spontaneous orientation test (patrolling behavior) in a cross-maze. It was(More)
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase. Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline. In anaesthetized cats, bromantan(More)
The influence of afobasol on threshold electrical fibrillation of the heart was studied in experiments on narcotized cats. It significantly elevated the cardiac fibrillation threshold in animals with intact myocardium and resembled class 1B anti-arrhythmic drug lidocaine in terms of this activity. Similar results were obtained using cats with denervated(More)
We studied modifications of EEG activity related to perception of visual stimuli (pictures) of the International Affective Picture System (IAPS) in women during different phases of the ovulatory (menstrual) cycle. We found that the woman’s brain is most intensely activated by both emotionally negative and positive visual stimuli during the follicular phase(More)
Intravenous injection of T3-146, a cyclic derivative of γ-aminobutyric acid (structural analog of piracetam), 5 min prior to reperfusion of the descendent branch of the left coronary artery prevents the development of serious rhythm disturbances and stabilizes hemodynamics and cardiac function. These effects are probably due to the inhibitory effect of this(More)