S. A. Kosterin

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The supramolecular compound calix[4]arene C-90 (5,11,17,23-tetra(trifluoro)methyl(phenylsulfonylimino)-methylamino-25,26,27,28-tetrapropoxycalix[4]arene) is shown to efficiently inhibit the ATP hydrolase activity of Ca2+,Mg2+-ATPase in the myometrium cell plasma membrane fraction and also in a preparation of the purified enzyme solubilized from this(More)
Calixarenes are supramolecular compounds interacting with bioactive molecules and ions, causing changes in biochemical and biophysical processes. The aim of this work was to study the effects of calix[4]arenes C-136, C-137, and C-138 at the level of polarization of the rat myometrium mitochondria membrane. The structure of synthesized calix[4]arene(More)
The effect of sigetin (dipotassium salt, meso-3, 4-di-(n-sulfophenyl)- hexane) on the electrical and mechanical activity, Ca2+, Mg2+-ATPase activity and Mg2+, ATP-dependent Ca2+ transport in uterine smooth muscle have been investigated. Sigetin caused depolarization of the cell membrane, leading to Ca2+ dependent spike discharge and development of(More)
Experiments performed on sarcolemmal vesicles isolated from uterine smooth muscle suggested the existence of two Ca 2 " transporting systems (ATP-driven Ca 2+ pump and Na + Ca 2+ exchange) (Kosterin et al. 1984). The functional role of these two energy-dependent Ca :+ transporting systems in the regulation of [Ca 2 ' ], and in the contraction-relaxation(More)
Studies on the vesicular fraction of myometrium sarcolemma showed that in the absence of initial Ca2+ gradient the vesicles activity accumulate Ca2+ by utilizing the energy of the antiport-directed Na+ gradient. Monensin (50 microM) suppresses practically completely the Ca2+ transport. The amount of Ca2+ entering the vesicles against the concentration(More)
Ca2+ concentration has been estimated in isolated myometrium cells using Ca2(+)-sensitive quin-2 fluorescent probe. Two components of Ca permeability of the plasmatic membrane have been determined, a potential-independent one (activated by K+ depolarization and nitrendipine-sensitive), and a basal one (not sensitive to nitrendipine). Smooth muscle cells(More)
It is proved that in the fraction of inverted vesicles of the myometrium sarcolemma there are two components of calcium metabolism which depend on the proton concentration in the incubation medium. The first component, a static one, identified under alkalization of the incubation medium from pH 6.0 up to pH 8.0 under equilibrium conditions (Ca2+(More)
Using a potential-sensitive fluorescent probe diS-C3-(5), the formation of the membrane (K+-diffusion) potential, delta psi, in the myometrium sarcolemmal vesicular fraction was demonstrated. The magnitude of this potential corresponds to that calculated according to the Nernst equation, is time-stable (characteristic dissociation time--3-5 min) and(More)
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