S A Komarets

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Immune responses were investigated in 118 patients suffering from chronic purulent inflammation of middle ear. All of them were operated under different methods of anesthesia. Immunotherapy preceding intravenous anesthesia with combination of phentanyl and clophelline along with supporting spontaneous breathing was found to be the most optimal from the(More)
The functional activity of cellular immunity was studied in 26 patients with opticochiasmatic arachnoiditis as a model of autoimmune involvement of the brain after administration of common anesthetics of different pharmacological groups. Injection of ketamine as the induction and basic component of general combined anesthesia leads to reduction of(More)
A system of individual immunotherapy is proposed which is based on the selection of an immunomodulator maximally suitable for the patients' immune system which is the therapeutic measure directed to the stimulation of forming the functional adaptive CNS dominant adequate to the pathological focus--the main component of sanogenesis in neuroanimatologic(More)
The analysis of immunological responsiveness and factors of nonspecific resistance in patients with relapsing meningiomas shows that there are prevalent autoimmune responses in the preoperative period and their gradual, but not final overcoming by the body after elimination of neoplastic relapse. At the same time the pathogenesis is closely associated with(More)
Analysing the body's responses in 32 patients operated on for cerebral vascular aneurysms has shown that preoperatively there is activation of the peripheral blood antiprotease system, which appears to be associated with the impaired permeability of the vascular wall and with the activation of the hemostatic system and that their liquores contain(More)
The authors show that brain tumors onset and relevant recurrences are closely related to enhanced synthesis of IgG in the liquor and of circulating immune complexes as well as to blocking factors registered in the liquor. The above facts illustrate autoimmune reactions involved in pathogenesis and recurrent growth of brain tumors. Surgical removal of the(More)
Brain tumor development and their recurrence are accompanied by an increase in IgG levels in liquor as well as in the number of circulating immunocomplexes and by the presence of blockage factors in liquor. The data presented in the paper, on the whole, illustrate the development of autoimmune reactions, which happen to be mechanisms involved in the(More)
The paper analyzes the time course of immune processes in the cerebrospinal fluid of patients with primary meningeal tumors of the brain. It shows the formation of an immunobiochemical neoplastic process of varying degrees in relation to the magnitude of tumor malignancy. The paper also considers if the local immune system can trigger sanogenetic mechanisms(More)
Pre- and postoperative immunochemical indices of cerebrospinal fluid (CSF) were investigated in 10 patients with fibrillary-protoplasmic astrocytoma and 10 patients with glioblastoma multiforme. Malignant neoplastic developments in the brain are associated with appearance of marked humoral reaction. Tumor-specific CSF changes observed comprise registration(More)