S. A. Goncharova

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The influence of methotrexate (MTX) on the proliferative activity of cells in different phases of cell cycle has been studied. MTX (5 mg/kg) was injected i.p. 3 days after the inoculation of 5 X 10(6) leukemia cells, into F1 (DBA X C57 BL) mice. It was shown that MTX causes degeneration of cells, being in G1- as well as in S-phase at the time of drug(More)
AIM Study previously unknown forms of persistence of Mycoplasma hominis in host organism. MATERIALS AND METHODS Culture method was used for detection of mycoplasmas. Identification was carried out by serological, electron microscopy methods, classic PCR and real time PCR; circulating immune complexes (CIC) were isolated by PEG precipitation. RESULTS(More)
AIM Study of possibility of generalization of mycoplasma infection in patients with urogenital pathology. MATERIALS AND METHODS Among the examined patients 5 males characterized by risky sexual behavior with pronounced symptoms of infection or without those were selected. Patients were examined by a complex of methods for the presence of mycoplasma(More)
The antigens, DNA and RNA of mycoplasmas are preset in the blood serum of persons infected with urogenital mycoplasmas. The planting of patients' tests of blood serum containing antigen M. hominis on the artificial growth mediums resulted in the growth of mini-colonies of mini-cells (20-50 nm). The colonies subcultured hardly but sometimes formed solid(More)
Treatment with low doses (1/10 of LD50) of cisplatin and platinum (IV)-nitroxyl complex VS118 [e-ammin-d-(4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl)-a,f-bi s(acetate)-b,c-dichlorplatinum (IV)] was followed by a synergistic therapeutic effect (a 100% cure of animals) as compared with monotherapy with either drug. There was no synergistic increase in(More)
It is known that several hours of intensive muscle tension result in accumulation of muscle derived enzymes and structural proteins (see review by Clarkson, 1997). We have assumed that, firstly, acute exposure to hypergravity may induce accumulation of serum creatine phosphokinase (CPK), and, secondly, level of that accumulation may be considerably altered(More)
In experimental animals with tumors it was studied antitumor activity of spirocyclic hydroxamic acids which could be classified as targeted agents as their target was enzyme histonedeacetylase, which was involved in the neoplastic process. The results showed that the hydroxamic acids were chemosensitizers for anticancer agents increasing their efficacy and(More)
The paper shows that aggregate hemagglutination reaction, enzyme immunoassays, and passive hemagglutination may be used in the laboratory diagnosis of Mycoplasma-induced infections. In patients with respiratory diseases of unknown origin, the M. pneumoniae antigen is easiest detected in the first days of the disease, then a long-term persistence of antigens(More)