S. A. Galetskii

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The present investigation was carried out to estimate the incidence of Epstein-Barr virus (EBV)-associated cases among gastric carcinoma (GC) patients in Russia. Carcinoma specimens from 184 patients with GC treated at the Cancer Research Center were investigated by EBV encoded RNA-1 (EBER-1) in situ hybridization. Seventeen (9.24%) cases showed uniform(More)
Representatives of various population groups in Azerbaijan were tested for infection with human T-lymphotropic (HTLV-I and HTLV-II) and hepatotropic viruses (HCV and HBV). A total of 835 sera were studied by screening and specific tests for virus-specific antibodies and/or antigens. Thirty-five DNA specimens from peripheral blood lymphocytes were analyzed(More)
Two type of exogenous action on transformed cells have been investigated. The first system includes clones of TWERC cells transformed by Rous sarcoma virus and cultivated in the presence of 5-bromodeoxyuridine. The second system consists of spontaneously transformed rat cells Sam IV superinfected with avian sarcoma virus B-77. In these cell lines and clones(More)
The link between papillomaviruses and human tumor pathology is one of the most important topics at the present time in oncovirology. The genetic information of human papillomaviruses (HPV) has been found by molecular-biological methods and cloned from cells of various human neoplasms, both benign and malignant. One of the latter is carcinoma of the uterine(More)
Nontumorigenic clone FR-7 cl 13 from fibroblasts of athymic rat was obtained from stroma of human colon carcinoma xenograft propagated on nude animals. Spontaneous transformation of this cells was absent after 40 passages in vitro and treatment with pSV2neo. But cells give rise to tumors in athymic mice after transfection with pEJ. This cell clone can be(More)
To obtain xenogeneic tumors at the present time immunodeficient animals, mainly nude mice, are used, for in this way it is possible to create a system for determining the tumorigenicity of cells [2, 3] and the factors of the host which affect tumor development [11]. Reports on the possible induction of transformation of an animal's stromal cells in(More)
Three new human cervical carcinoma xenografts was established from clinical tumor specimens of patients with I-II stages of disease. Growth characteristics of models are writing. Xenografts designated CC 9, 24 and 25 contain integrated DNA HPV, complemented DNA HPV-16. DNA CC 5 contain neither DNA HPV-16, nor DNA HPV-18.
Integration, transcription and translation of Rous sarcoma virus (RSV) genome was analyzed in transformed rat fibrosarcoma XC cells (non-virus producing). About ten copies of RSV genome were integrated into the host cell genome. Different types of viral RNA were identified in the cytoplasmic fraction whose sedimentation values were nearly the same as for(More)
An antimyeloblastic immune serum (AMS) was prepared by immunizing horses with white blood cells (WBC) from a patient with chronic myeloid leukemia (CML) in the blast crisis stage. The serum was exhausted in relation to antibodies against red and white blood cells of healthy donors. The AMS continued to have a cytotoxic action on blast cells from the blood(More)
Xenograft CC-32 was obtained from uterine cervical carcinoma of 24 years old woman in IV stage of the disease. Morphological diagnosis of clinical material and xenograft at various passages was the same-squamous cell carcinoma. Examination tumour DNA showed HPV-16 DNA integrated in five selected points. Tumor CC-32 contained a large quantity a diploid and(More)