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A tissue-based biosensor is described for screening chemical compounds that rapidly affect the nervous system. The proposed sensor is an extension of a previous work on cultured hippocampal slices [Biosens. Bioelectron. 16 (2001) 491]. The detection of the chemical compounds is based on a novel quantification method of short-term plasticity (STP) of the CA1(More)
Group A streptococcus (GAS) is associated with a spectrum of soft-tissue infections that include toxic shock syndrome, myositis, and necrotizing fasciitis (1, 2, 3). The mainstay of therapy for invasive GAS soft-tissue infections is surgical exploration and debridement, as penicillin treatment alone is associated with a high morbidity and mortality (4). We(More)
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