S. A. Borisenko

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A new COMT inhibitor, nitecapone (OR-462) or clorgyline, a MAO-A inhibitor, was infused into the 3rd brain ventricle (i.c.v.) of conscious male rats. None of the enzyme inhibitors given alone alter hypothalamic or striatal levels of L-dopa, dopamine or their metabolites. Most of the rats were pretreated with levodopa/carbidopa (LD/CD, 15/30 mg kg-1(More)
This study deals with the karyotype of the flathead sculpin Megalocottus platycephalus platycephalus (Pallas, 1814) (family Cottidae) from Odyan Bay of the Sea of Okhotsk. The karyotype is stable: 2n = 42 (2 metacentric, 2 submeta-subtelocentric, 30 subtelocentric, and 8 acrocentric chromosomes), NF = 44 + 2. The nucleolar organizers (NOs) were identified(More)
We studied effects of anxiogenic and anxiolytic compounds on the electric self-stimulation of the medial fore-brain bundle in male rats to find out if there is a link between reward and anxiety-related behaviours. The cholecystokinin agonist, caerulein (25-100 micrograms/kg) and the 5-HT agonist 1-(3-chlorophenyl)piperazine (0.2-1 mg/kg) dose-dependently(More)
For the first time, we studied the karyotype of the flathead sculpin Megalocottus platycephalus taeniopterus (Kner, 1868) from Vostok Bay of the Sea of Japan. The karyotype is stable: 2n = 42 (2 metacentric, 2 submeta-subtelocentric, 30 subtelocentric, and 8 acrocentric chromosomes), NF = 44 + 2. The nucleolar organizers (NOs) were identified using Ag(More)
We examined behavioral and biochemical specificity and the general usefulness of the proposed rat model of Alzheimer's disease. Bilateral infusions of ethylcholine aziridinium (AF64A) into the basal magnocellular nuclei caused a deterioration of learning in passive and active avoidance tests, increased emotional reactivity, and decreased motoric activity.(More)
The effect of morphine on cold-stimulated secretion of TSH and prolactin was studied in male rats, both in acute studies and after the chronic administration of morphine for 14 days (twice a day with increasing doses). The duration of the stimulatory effect of a single dose of morphine on secretion of prolactin was shorter (less than 2 hr) than its(More)
It has been shown that intraperitoneal injection of alcohol in a single subnarcotic dose decreases 3H-GABA accumulation in the medulla oblongata, hypothalamus, nucleus caudatus, cortex, and thalamus. When given in a narcotic dose alcohol produces biphasic changes in 3H-GABA accumulation by the brain: an increase within the period of narcosis and a reduction(More)
D-amphetamine and cocaine were found to facilitate septal self-stimulation. In low doses morphine, imipramine, benactyzine, meprobamat, diazepam, chlordiazepoxide, phenobarbital, LSD-25 failed to influence this index, but in high doses they depressed the self-stimulation. It is supposed that d-amphetamine and cocaine exerted a direct stimulating action of(More)
The development of cross tolerance to morphine, amphetamine and alcohol according to their activating effect on the system of positive reinforcement of the brain was shown on the basis of experimental self-stimulation reaction. It is assumed that the common neurophysiological and neurochemical mechanisms, particularly the adrenergic mechanisms of the system(More)
A study was made of the effect of morphine, promedol, phentanyl, pentazacine and psychostimulant d,l-amphetamine on the threshold of pain sensitivity and self-stimulation of the hypothalamus and the septum in rats. Electrical stimulation of the systems of positive reinforcement of the hypothalamus and the septum, and also analgetics increased the threshold(More)