S. A. Borisenko

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We studied effects of anxiogenic and anxiolytic compounds on the electric self-stimulation of the medial fore-brain bundle in male rats to find out if there is a link between reward and anxiety-related behaviours. The cholecystokinin agonist, caerulein (25-100 micrograms/kg) and the 5-HT agonist 1-(3-chlorophenyl)piperazine (0.2-1 mg/kg) dose-dependently(More)
It has been demonstrated that membrane-stabilizing agents, chlorpromazine and alpha-tocopherol, have no effect on the increased blood-brain barrier permeability for 14C-tyrosine, induced by a single injection of ethanol at a dose of 2 and 4 g/kg. Dopaminergic antagonist haloperidol prevented the increase of blood-brain barrier permeability induced by a(More)
A new COMT inhibitor, nitecapone (OR-462) or clorgyline, a MAO-A inhibitor, was infused into the 3rd brain ventricle (i.c.v.) of conscious male rats. None of the enzyme inhibitors given alone alter hypothalamic or striatal levels of L-dopa, dopamine or their metabolites. Most of the rats were pretreated with levodopa/carbidopa (LD/CD, 15/30 mg kg-1(More)
Male Wistar rats were divided in free choice conditions into heavy-drinkers consuming greater than 3.5 g/kg of ethanol daily (HD), and light-drinkers consuming less than 2.0 g/kg/day (LD). Subsequent 30 day intragastric administration of 25% ethanol (8-11 g/kg/day) caused an increase in permeability of the BBB to 14C-tyrosine, 14C-tryptophan and 14C-DOPA at(More)
The karyotype of the endemic Okhotsk Sea sculpin Myoxocephalus ochotensis Schmidt (Cottidae) from Odyan Bay was studied. The number and morphology of chromosomes were determined, 2n = 42 (2 metacentric, 20 subtelocentric, and 20 acrocentric chromosomes), NF = 44. Variability of chromosome number was not revealed; no difference between male and female(More)
This study deals with the karyotype of the flathead sculpin Megalocottus platycephalus platycephalus (Pallas, 1814) (family Cottidae) from Odyan Bay of the Sea of Okhotsk. The karyotype is stable: 2n = 42 (2 metacentric, 2 submeta-subtelocentric, 30 subtelocentric, and 8 acrocentric chromosomes), NF = 44 + 2. The nucleolar organizers (NOs) were identified(More)
A new embryonic antigen was found in ovarian tumors by methods of immunodifusion analysis. This antigen consists of two components with different electrophoretic mobilities: The slow peak migrates in the αo-globulin zone, the fast peak in the prealbumin zone. It is immunologically different from α-fetoprotein and from the carcinoembryonic antigen of the(More)
Previously we have demonstrated that the reactions of , -dihalogen-substituted valeric, caproic, and enanthic acids with amines offer a convenient pathway for the synthesis of -pyrrolidine[2], -piperidine[3], and ( -hexamethyleneimine)carboxylic acids [4]. In continuation of these investigations, we have studied the reactions of primary amines with ,(More)
Blood serum levels of ferritin and trophoblastic globulin were measured by immunoassay in 389 and 114 cases, respectively, suffering malignant or benign tumors of the uterus and ovary as well as in controls. Hyperferritinemia identified at serum ferritin levels in excess of 200 micrograms/l was established in 94% of cases of ovarian cancer, 57%--benign(More)
Antisera were obtained by rabbits immunization with pooled extract from ovarian carcinoma and its metastases into the ome tum. Using standard test-system antigen, precipitating in agar, was identified in the tissue of 12 out of 24 primary ovarian carcinomas and in 8 out of 20 metastases. It was not revealed in adult healthy internal organs tissues and in(More)