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The hypofrontality theory of the pathogenesis of schizophrenia predicts that cortical lesions cause psychosis. During a search for abnormalities of catecholaminergic neurotransmission in patients with complex partial seizures of the mesial temporal lobe, we discovered an increase of the rate of metabolism of an exogenous dopa tracer (6-[18F]fluoro-L-dopa)(More)
A review of brain imaging (PET and MRI) studies on schizophrenia and recent data from neuroanatomy, neurophysiology, neuropathology, neurochemistry, neuropsychology, and cortical organization theory is integrated with the concept of local circuit neurons (LCNs) in a new hypothesis--the local circuit neurons hypo(dys)function hypothesis of(More)
It has been suggested that nitric oxide, a nonconventional intra- and intercellular messenger involved in various biological and nervous system functions, may play a crucial role in a sophisticated cerebral microvascular system that regulates cerebral blood flow (CBF) under resting and activated conditions. A review of regional cerebral blood flow (rCBF)(More)
The study explored associations between the cerebral event-related slow potentials (ERSP) and psychiatric symptoms and syndromes as reflected by the Present State Examination (PSE) in 36 randomly selected psychiatric in-patients. Independent raters measured the readiness potential (RP), contingent negative variation (CNV) and post-imperative negative(More)
  • M Axato, G Bagdy, +13 authors Royal Ottawa
  • 2005
titles were selected for inclusion here on the basis of their direct relevance to schizophrenia. Judgments about the quality of the article or book have been left to the reader. Due to space limitations, the Schizophrenia Bulletin has temporarily discontinued categorizing the bibliography and publishing the abstracts themselves; however, we hope to(More)
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