Søren Schou Olesen

Jens Brøndum Frøkjær3
Jesper Bach Hansen2
Stefan A W Bouwense2
3Jens Brøndum Frøkjær
2Jesper Bach Hansen
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OBJECTIVE Conditioning Pain Modulation (CPM) represents the various descending inhibitory mechanisms induced by a heterotopic noxious stimulation (previously termed DNIC). CPM-induced modulations in brain activity have not previously been investigated to visceral pain. Hence the aims were to assess the role of CPM in terms of: (1) psychophysics, (2)(More)
  • Jens Brøndum Frøkjær, Søren Schou Olesen, Mikkel Gram, Yousef Yavarian, Stefan A W Bouwense, Oliver H G Wilder-Smith +1 other
  • 2011
OBJECTIVE In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. (More)
BACKGROUND & AIMS Patients with painful chronic pancreatitis (CP) might have abnormal brain function. We assessed cortical thickness in brain areas involved in visceral pain processing. METHODS We analyzed brain morphologies of 19 patients with painful CP and compared them with 15 healthy individuals (controls) by using a 3T magnetic resonance scanner. By(More)
INTRODUCTION Several brain structures have been consistently found to be involved in visceral pain processing. However, recent research questions the specificity of these regions and it has been suggested that it is not singular activations of brain areas, but their cross-communication that results in perception of pain. Moreover, frequency at which neurons(More)
BACKGROUND AND AIM Hepatic encephalopathy (HE) is a severe and frequent complication of liver cirrhosis characterized by abnormal cerebral function. Little is known about the underlying neural mechanisms in HE and human data are sparse. Electrophysiological methods such as evoked brain potentials after somatic stimuli can be combined with inverse modeling(More)
OBJECTIVE Alterations of the electroencephalogram (EEG) have been reported in patients with hepatic encephalopathy (HE). However, previous methods have not assessed transient phenomena in the EEG signal (dynamics) and associations to psychometric test performance have in general been poor. The aims were to quantify spectral and dynamic EEG abnormalities in(More)
Pain is common in gastroenterology. This review aims at giving an overview of pain mechanisms, clinical features, and treatment options in oesophageal disorders. The oesophagus has sensory receptors specific for different stimuli. Painful stimuli are encoded by nociceptors and communicated via afferent nerves to the central nervous system. The pain stimulus(More)
BACKGROUND/AIMS In various chronic pain conditions cortical reorganisation seems to play a role in the symptomatology. The aims of this study were to investigate cortical reorganisation in patients with pain caused by chronic pancreatitis (CP) and to correlate putative cortical reorganisation to clinical pain scores. METHODS 24 patients suffering from CP(More)
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