Søren Martin Madsen

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It is widely accepted that hypoperfusion and changes in capillary morphology are involved in the etiopathogenesis of Alzheimer's disease (AD). This is difficult to reconcile with the hyperperfusion observed in young high-risk subjects. Differences in the way cerebral blood flow (CBF) is coupled with the local metabolic needs during different phases of the(More)
BACKGROUND To evaluate the use of low-field magnetic resonance imaging (MRI) in active inflammatory bowel disease (IBD). METHODS MRI was executed in a consecutive cohort of 28 patients with Crohn disease (CD) and in 17 with ulcerative colitis (UC) prior to glucocorticoid treatment (1 mg prednisolone orally/kg body weight/day). MRI was repeated after 2-3(More)
The attitudes of women patients with cancer were explored when they were invited to participate in one of three randomised trials that included chemotherapy at two university centres and a satellite centre. Fourteen patients participating in and 15 patients declining trials were interviewed. Analysis was based on the constant comparative method. Most(More)
OBJECTIVES To investigate attitudes to clinical research amongst cancer trial participants and nonparticipants, and to compare results with those from previous studies amongst participants in noncancer trials. DESIGN Trial participating respondents were given three questionnaires during the clinical trials. Respondents amongst patients declining(More)
OBJECTIVES To investigate attitudes to clinical research amongst potential research participants. DESIGN Questionnaire-survey. SETTING Two medical out-patient clinics and the background population. SUBJECTS A total of 508 randomly selected citizens in Copenhagen County (64% responded) and 200 consecutive patients attending the out-patient clinics (64%(More)
BACKGROUND Patients suspected of having perianal suppurative disease often undergo a combination of several potentially painful, invasive procedures to establish or rule out the diagnosis. To evaluate the accuracy of low-field magnetic resonance imaging (MRI) in distinguishing patients with active anal fistulae and patients with no active fistulation we(More)
AIM To investigate the preferred extent of written information in clinical trials among potential and actual trial participants. MATERIALS AND METHODS Questionnaire survey among citizens of Copenhagen County (PUB, N=508), patients attending an out-patient clinic (OPC, N=200), and finally among participants in two clinical trials (ROC, N=32; MRCRUC,(More)
A simple filter-paper method for in vivo assessment of cytokines in intestinal mucosa of patients with ulcerative colitis (UC) was developed and evaluated. Twenty-eight patients were included. Twenty-three patients had ulcerative colitis (UC) and five irritable bowel syndrome (IBS). Inflammation was assessed endoscopically. Through a rectoscope, filter(More)
OBJECTIVE:The aim of this study was to compare the treatment efficacies of subcutaneous interferon-α-2A (IFN-α-2A) injections versus prednisolone enemas in active left-sided ulcerative colitis in an open-labeled, randomized study.METHODS:Sixteen ulcerative colitis patients received IFN-α-2A subcutaneously (dosage: first wk, 9 MIU three times weekly(More)
The principle of respect for patients' autonomy, or right to self-determination, has gained increasing importance in health care legislation during the last decade. To respect this principle the patients' informed consent to a proposed treatment is required. In relation to ordinary treatments in general practice, where several reasonable alternatives may be(More)