Søren Krabbe

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The aim of the present study was to assess growth, final height, growth hormone (GH) secretion and growth factors after BMT including TBI in childhood. The median age of the 25 participants was 11.3 years at BMT, and a median of 7.5 years had elapsed since BMT. The median height standard deviation score (SDS) declined significantly from diagnosis until 4(More)
Testicular biopsy specimens from 4 (8%) of 50 men previously treated for maldescended testes had a carcinoma-in-situ pattern. 2 of these men had adjacent invasive carcinoma (seminoma and embryonal carcinoma). The patient with embryonal carcinoma had an enlarged testis but the 3 other patients with neoplasia had no clinical signs or symptoms of malignancy.(More)
A total number of 23 patients treated with human growth hormone were retested by use of a combined pituitary stimulation test. Plasma concentrations of GH, FSH, LH, TSH, T4, T3, prolactin (PRL), ACTH and cortisol were measured before and after stimulation with hypoglycemia, TRH and LHRH. The test was performed in patients with persistent GH deficiency(More)
Central precocious puberty (CPP) is characterized by early activation of the pituitary-gonadal axis, which leads to increased growth velocity and development of secondary sexual characteristics. It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding(More)
With the purpose of studying calcium metabolism at the growth spurt phase in puberty, bone mineral content (BMC) of the forearm, and serum concentrations of total alkaline phosphatase, phosphate, and calcium were determined in 36 boys every three months for about 2 years. BMC increased 35% throughout the study age period of 10.6 to 14.6 years, with a(More)
A material of fifteen children aged 10 months to 15 years with infectious mononucleosis (IM) was investigated. The diagnosis was established by demonstration of Epstein-Barr virus (EBV) specific IgM antibodies. The serum concentrations of beta 2-microglobulin (beta 2-m) were significantly increased (p less than 0.01) in the first sample after onset of(More)
ABOUT 1000 of testicular germ-cell tumours occur in men treated for maldescended testes (Whitaker, 1970). The risk of testicular tumour in men with maldescended testes has been estimated at 35 times that of normal men (Whitaker, 1970). Recently 2 case-control studies confirmed the increased risk of testicular tumour in maldescended testes (Morrison, 1976;(More)
Calcium homoeostasis and bone mineralization have been the subject of many studies, but few have dealt with these aspects specifically in puberty. The main observations in our own studies - together with those in other recent reports - are summarized below. According to the aims of the present survey (Chapter 1) the results are grouped as follows: BLOOD(More)
Two brothers, 16 and 14 years of age, with hypogonadotrophic hypogonadism and anosmia were treated with subcutaneous injections of 200 microng gonadotropin-releasing hormone at 8-hour intervals for 4 weeks. Serum FSH increased to the range of normal adult men, but serum LH and serum testosterone showed little change and no clinical signs of pubertal(More)
A rare cause of Cushing's syndrome is a pituitary-independant nodular dysplasia of the adrenal cortex. A 4 year old girl presented with advanced clinical features of Cushing's syndrome. Abdominal CT-scan and adrenal scintigraphy revealed bilateral adrenal hyperplasia whereas a cerebral CT-scan was normal. Serial determinations of plasma ACTH together with(More)