Søren Berndt Hansen

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BACKGROUND AND AIMS OF THE STUDY Turbulences downstream of mechanical aortic valves are known to contribute to most valve-related complications such as thrombosis, embolization or damage to blood components. In vitro studies have demonstrated the impact of the orientation of prostheses on transvalvular energy loss. This study evaluates the influence of(More)
OBJECTIVE High intensity transient signals (HITS) representing microembolization to the brain have been found to contribute to cognitive impairment and psychoneurological dysfunction in patients carrying a mechanical aortic valve. It is unknown, whether HITS represent gaseous or solid emboli. This animal study evaluates the impact of valve orientation on(More)
BACKGROUND In previous studies [1,2], the impact of valve orientation on the hemodynamic performance of mechanical aortic valves has been demonstrated. This study investigates Turbulence (RNS values) and High Intensity Transient Signals (HITS) as a new and objective parameter for hemodynamics in different orientations of Medtronic Hall (MH) and St. Jude(More)
BACKGROUND AND AIM OF THE STUDY Chordae tendineae may be instrumental for valvular-ventricular interaction, i.e. the reciprocal exchange of force between the left ventricular myocardium and the mitral apparatus. Chordae tendineae are divided into primary leading edge chordae and secondary belly chordae, and differences in thickness and distribution may(More)
BACKGROUND Ischemic mitral regurgitation is caused by an imbalance of the entire mitral-ventricular complex. This interaction is mediated through the chordae tendineae force distribution, which may perturb several elements of the mitral valve apparatus. Our objective was to investigate the association between the mitral valvular 3-dimensional geometric(More)
Cardiomyoplasty is an experimental treatment for end-stage heart failure. We hypothesized that the porcine latissimus dorsi muscle (LDM) in an experimental porcine model is a suitable surrogate for a clinically relevant evaluation of this concept. Fourteen Danish Landrace (DL) pigs and six Göttingen minipigs (GM) were studied. The LDM was evaluated(More)
BACKGROUND AND AIM OF THE STUDY Patients with mechanical heart valves must endure the valve's closing sounds for the rest of their life. Sound pressure levels (SPLs) recorded show wide patient-to-patient variation, even for the same type of valve. The variation was attributed to body constitution variability and differences in hemodynamic status. It was(More)
A general hindrance to progress in adoptive cellular therapy is the lack of detailed knowledge of the fate of transferred cells in the body of the recipient. In this study, we present a novel technique for tracking of 124I-labeled cells in situ, which combines the high spatial resolution of magnetic resonance imaging with the high sensitivity and spatial(More)
The possible use of silver as a material for in vivo dosimetry in radiotherapy was investigated. The investigation was carried out using a positron emission tomography (PET) scanner, two clinical accelerators and a phantom with silver implants. The phantom was irradiated several times to doses between 6 and 45 Gy. The resulting activity of positron-emitting(More)
BACKGROUND Diabetic retinopathy (DR) is the most frequent cause of blindness among younger adults in the western world. No blood biomarkers exist to detect DR. Hypothetically, Rhodopsin concentrations in blood has been suggested as an early marker for retinal damage. The aim of this study was therefore to develop and validate a Rhodopsin assay by employing(More)