Sílvia Cristina Dias Pinto

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BACKGROUND Acute exposure of part of the skin to cold stimuli can evoke urinary urgency, a phenomenon termed acute cold-induced urgency (ACIU). Despite its high prevalence, particularly in patients with overactive bladder, little is known about the mechanisms that induce ACIU. OBJECTIVE To develop an animal model of ACIU and test the involvement of(More)
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disorder presenting with motor impairment and autonomic dysfunction. Urological function is altered in the majority of MSA patients, and urological symptoms often precede the motor syndrome. To date, bladder function and structure have never been investigated in MSA models. We aimed to test(More)
BACKGROUND First-line pharmacotherapy for overactive bladder consists of anticholinergics. However, patient compliance is exceptionally low, which may be due to progressive loss of effectiveness. OBJECTIVE To decipher the involved molecular mechanisms and to evaluate the effects of chronic systemic administration of anticholinergics on bladder function(More)
PURPOSE During cystitis, increased innervation of the bladder by sensory nerves may contribute to bladder overactivity and pain. The mechanisms whereby cystitis leads to hyperinnervation of the bladder are, however, poorly understood. Since TRP channels have been implicated in the guidance of growth cones and survival of neurons, we investigated their(More)
This article describes the use of the 2D wavelet transform to estimate the multiscale gradient of two types of cortical sulci, from which two potentially discriminating features, namely the gradient mean magnitude and entropy of its orientation distributions, are calculated. The obtained results coroborates the potential of such multiscale geometrical(More)
This work presents a new approach for the 3D human facial expressions analysis. Our methodology is based on 2D and 3D wavelet transforms, which are used to estimate multi-scale features from real a face acquired by a 3D scanner. The proposed methodology starts by considering a dataset composed by faces displaying seven different facial expressions. An(More)
The lower urinary tract (LUT) functions as a dynamic reservoir that is able to store urine and to efficiently expel it at a convenient time. While storing urine, however, the bladder is exposed for prolonged periods to waste products. By acting as a tight barrier, the epithelial lining of the LUT, the urothelium, avoids re-absorption of harmful substances.(More)
This paper presents a new approach for the morphome-trical characterization of brain structures using shape features calculated from normal fields. An orientable surface representation of the brain structure is derived allowing the estimation of the corresponding normal field without the need of a parameterized surface. In fact, the normal field is(More)
BACKGROUND This feasibility study established an experimental protocol to evaluate brain activation patterns using fluorodeoxyglucose positron emission tomography ((18F)FDG-PET) during volume-induced voiding and isovolumetric bladder contractions in rats. METHODS Female Sprague-Dawley rats were anaesthetized with urethane and underwent either(More)
The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8(More)