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OBJECTIVES To understand the treatment goals of Alzheimer's disease (AD) patients, carers, and physicians; to estimate whether clinically important goals are met during treatment with donepezil; and to compare a measure of goal attainment with standard measures used to evaluate AD treatment. METHODS In a 12 month phase IV trial, 108 patients with mild to(More)
The aim of the present experiment was to investigate whether educational level could modulate the effect of aging on episodic memory and on the electrophysiological correlates of retrieval success. Participants were divided into four groups based on age (young vs. older) and educational level (high vs. low), with 14 participants in each group. Event-related(More)
Recent behavioural and imaging data have shown that memory functioning seems to rely more on executive functions and on the prefrontal cortex (PFC) in older than in young adults. Using a behavioural approach, our objective was to confirm the hypothesis that young and older adults present different patterns of correlation between episodic memory performance(More)
This experiment investigated age differences in electrophysiological correlates of retrieval success in a word-stem cued recall task. Young adults (M+/-SD: 21.4 years+/-1.9) performed this memory task more accurately than older participants (M+/-SD: 65.1 years+/-3.3). Robust event-related brain potential (ERP) old/new effects were identified in both age(More)
The aim of this study was to investigate the effect of advanced age on self-reported internal and external memory strategy uses, and whether this effect can be predicted by executive functioning. A sample of 194 participants aged 21 to 80 divided into three age groups (21-40, 41-60, 61-80) completed the two strategy scales of the Metamemory in Adulthood(More)
The present experiment investigates the involvement of awareness in functional dissociations between explicit and implicit tests. In the explicit condition, participants attempted to recall lexically or semantically studied words using word stems. In the implicit condition, they were instructed to complete each stem with the first word which came to mind.(More)
The present study investigated the effects of aging on behavioral cued-recall performance and on the neural correlates of explicit memory using event-related potentials (ERPs) under shallow and deep encoding conditions. At test, participants were required to complete old and new three-letter word stems using the letters as retrieval cues. The main results(More)
In this event-related evoked potentials (ERP) study, the neural correlates of a group of highly educated older adults were compared with those of a group of young adults while performing a word-stem completion priming task under semantic and lexical encoding conditions. The results revealed that both age groups exhibited robust priming. The older(More)
BACKGROUND Misplacing objects is a commonly reported symptom of Alzheimer's disease (AD) but it is little described systematically and conflicting characterisations (losing/forgetting the location of objects versus inappropriate placement) of this "warning sign" of dementia currently exist. Patient and carer descriptions of misplacing in clinical interviews(More)
This experiment examines whether the age-related decrease in the generation effect of rhymes is mediated by executive functioning. Young and elderly adults read and generated pairs of rhyming words for subsequent recall. Participants were also administered neuropsychological tests (executive and mnemonic functions). Results showed that elderly adults(More)