Séverine Fay

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OBJECTIVES To understand the treatment goals of Alzheimer's disease (AD) patients, carers, and physicians; to estimate whether clinically important goals are met during treatment with donepezil; and to compare a measure of goal attainment with standard measures used to evaluate AD treatment. METHODS In a 12 month phase IV trial, 108 patients with mild to(More)
The aim of the present experiment was to investigate whether educational level could modulate the effect of aging on episodic memory and on the electrophysiological correlates of retrieval success. Participants were divided into four groups based on age (young vs. older) and educational level (high vs. low), with 14 participants in each group. Event-related(More)
This experiment investigated age differences in electrophysiological correlates of retrieval success in a word-stem cued recall task. Young adults (M+/-SD: 21.4 years+/-1.9) performed this memory task more accurately than older participants (M+/-SD: 65.1 years+/-3.3). Robust event-related brain potential (ERP) old/new effects were identified in both age(More)
The present experiment investigates the involvement of awareness in functional dissociations between explicit and implicit tests. In the explicit condition, participants attempted to recall lexically or semantically studied words using word stems. In the implicit condition, they were instructed to complete each stem with the first word which came to mind.(More)
This experiment explored the functional significance of age-related hemispheric asymmetry reduction associated with episodic memory and the cognitive mechanisms that mediate this brain pattern. ERPs were recorded while young and older adults performed a word-stem cued-recall task. Results confirmed that the parietal old/new effect was of larger latency and(More)
Executive functioning and memory impairment have been demonstrated in adults with depression. Executive functions and memory are related, mainly when the memory tasks require controlled processes (attentional resource demanding processes)--that is, when a low cognitive support (external aid) is provided. A cross-sectional study was carried out on 45(More)
The current experiment aimed to explore age differences in brain activity associated with successful memory retrieval in older adults with different levels of executive functioning, at different levels of task demand. Memory performance and fMRI activity during a recognition task were compared between a young group and two older groups characterized by a(More)
BACKGROUND Misplacing objects is a commonly reported symptom of Alzheimer's disease (AD) but it is little described systematically and conflicting characterisations (losing/forgetting the location of objects versus inappropriate placement) of this "warning sign" of dementia currently exist. Patient and carer descriptions of misplacing in clinical interviews(More)
In this event-related evoked potentials (ERP) study, the neural correlates of a group of highly educated older adults were compared with those of a group of young adults while performing a word-stem completion priming task under semantic and lexical encoding conditions. The results revealed that both age groups exhibited robust priming. The older(More)
The aim of this study was to investigate the effect of advanced age on self-reported internal and external memory strategy uses, and whether this effect can be predicted by executive functioning. A sample of 194 participants aged 21 to 80 divided into three age groups (21-40, 41-60, 61-80) completed the two strategy scales of the Metamemory in Adulthood(More)