Sérgio Ossamu Ioshii

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Hepatitis C virus (HCV) is a major cause of hepatic disease and of liver transplantation worldwide. Mannan-binding lectin (MBL), encoded by the MBL2 gene, can have an important role as an opsonin and complement activating molecule in HCV persistence and liver injury. We assessed the MBL2 polymorphism in 102 Euro-Brazilian patients with moderate and severe(More)
First submission on 16/01/13; last submission on 02/08/13; accepted for publication on 05/08/13; published on 20/10/13 1. Doctorate in Clinical Surgery from Universidade Federal do Paraná (UFPR); pathologist at Hospital Erasto Gaertner. 2. Doctorate in Pathology from Mie University, Japan; associate professor at UFPR and Pontifícia Universidade Católica do(More)
OBJECTIVE A previously unrecognized high prevalence of celiac disease (CD) has been found by screening among European and North American patients with type 1 diabetes mellitus (DM 1). The prevalence of CD among Brazilian children with DM1 is not known. This study was conducted to determine the prevalence of CD in Brazilian children and adolescents with DM(More)
AIM To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A (IgA) antitransglutaminase antibody. METHODS Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba(More)
The authors report on the incidence and clinical characteristics of neuroblastoma in southern Brazil. The aims of the study were to evaluate the age at diagnosis, tumor stage, MYCN status, and tumor histopathology, and to relate these factors to survival. All patients with neuroblastoma, 15 years old or younger (n = 125), admitted to the three major(More)
BACKGROUND The involvement of HPV in oral and oropharyngeal carcinogenesis was first proposed in 2004, based on epithelial HPV tropism and detection of HPV genotypes in oral squamous cell carcinoma samples. While 60-70% of oropharynx tumors may be HPV-positive, only 10 to 19% of tumors of the oral cavity, larynx and hypopharynx appear to have HPV infection.(More)
AIM The aim of the present study was to correlate the serological methods of coeliac disease diagnostic tests (IgA EmA and IgA anti-tTG) with the histological findings of the duodenal mucosa. METHODS AND RESULTS Forty-seven patients were studied and the data were analysed by the Pearson correlation. Seven patients (15%) with normal mucosa were negative(More)
OBJECTIVE To study the effects of repeated injections of betamethasone on proteoglycan concentration in the articular cartilage of normal knees of Californian rabbits of both sexes. METHODS Eighty animals were randomly divided into eight groups of ten animals each. Three control groups (saline solution injected or not) and five study groups -(More)
PURPOSE Hypothyroidism is a common situation among the aged which affects protein synthesis. The objective of the present study was to determine the influence of hypothyroidism on the healing process in aged rats. METHODS 96 male Wistar rats were used, 48 of them with a mean age of 110 days and 48 with a mean age of 750 days. Half the young animals and(More)
Sarcomatoid carcinoma is a rare variant of malignant tumor arising from the urinary tract. This tumor had been termed carcinosarcoma because of its carcinomatous and sarcomatous components. There is still some confusion in the terminology between true carcinosarcoma and sarcomatoid carcinoma; however, the latter is now regarded as primarily a malignant(More)