Sébastien Ulrich

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Bisfunctionalized guanidinium compounds displaying aromatic side groups of varying size are shown to self-assemble in aqueous solution with single-stranded DNA through phosphodiester backbone recognition. Competition experiments indicate the importance of π-stacking interactions in the stabilization of these DNA-templated supramolecular self-assemblies.
DNA-templated self-assembly is an emerging strategy for generating functional supramolecular systems, which requires the identification of potent multi-point binding ligands. In this line, we recently showed that bis-functionalized guanidinium compounds can interact with ssDNA and generate a supramolecular complex through the recognition of the(More)
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