Sébastien Nola

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SNAREs constitute the core machinery of intracellular membrane fusion, but vesicular SNAREs localize to specific compartments via largely unknown mechanisms. Here, we identified an interaction between VAMP7 and SNAP-47 using a proteomics approach. We found that SNAP-47 mainly localized to cytoplasm, the endoplasmic reticulum (ER), and ERGIC and could also(More)
Vesicular (v)- and target (t)-SNAREs play essential roles in intracellular membrane fusion through the formation of cytoplasmic α-helical bundles. Several v-SNAREs have a Longin N-terminal extension that, by promoting a closed conformation, plays an autoinhibitory function and decreases SNARE complex formation and membrane fusion efficiency. The molecular(More)
Breast cancer is the most commonly diagnosed and the second highest cause of cancer-related mortality. Although major breakthroughs have emerged during the past decades concerning the characterization of major malignant tumors hallmarks, little is known about the molecular process that sustains the most deadly feature of cancer: metastasis to distant(More)
INSERM; U950; Membrane Traffic in Health and Disease; Paris, France; Univ Paris Diderot; Sorbonne Paris Cit e; ERL U950; Paris, France; CNRS; UMR 7592; Institut Jacques Monod; Paris, France; State Key Laboratory of Molecular Developmental Biology; Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, China; Institut Curie;(More)
VARP and LRRK1 2 Guan Wang1,2, Sébastien Nola1,2, Simone Bovio3, Maïté Coppey-Moisan4, Frank Lafont3, and Thierry 3 Galli1,2* 4 1 Membrane Traffic in Health & Disease, Institut Jacques Monod, CNRS UMR7592, INSERM U950, 5 Sorbonne Paris-Cité, Université Paris Diderot, 75205 Paris, France 6 2 Trafic membranaire normal et pathologique, Centre de Psychiatrie et(More)
Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular parasite that exploits different host vesicular pathways to invade the target cells. Vesicular and target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are key proteins of the intracellular membrane fusion machinery. During the early(More)
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