Sébastien Lecommandoux

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Plitidepsin is an antineoplasic currently in clinical evaluation in a phase III trial in multiple myeloma (ADMYRE). Presently, the hydrophobic drug plitidepsin is formulated using Cremophor®, an adjuvant associated with unwanted hypersensitivity reactions. In search of alternatives, we developed and tested two nanoparticle-based formulations of plitidepsin,(More)
Polymer vesicles polymersomes are vesicles obtained from the self-assembly of amphiphilic block copolymers in aqueous solution as a result of free-energy minimization. [1] Their potential use as drug delivery systems, [2] sensors, and/or nanoreactors [3] has recently attracted a great deal of interest. [4] Polymersomes exhibit larger mechanical stability(More)
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