Polymer vesicles polymersomes are vesicles obtained from the self-assembly of amphiphilic block copolymers in aqueous solution as a result of free-energy minimization.  Their potential use as drug delivery systems,  sensors, and/or nanoreactors  has recently attracted a great deal of interest.  Polymersomes exhibit larger mechanical stability… (More)
Block copolymers combining peptide and saccharide moieties may play a significant role in future applications of polymers in biology, as they can be viewed as simplified synthetic analogues of glycosylated proteins, which display a wide range of biological functions in nature. While a small number of oligosaccharides containing synthetic polypeptides have… (More)
Plitidepsin is an antineoplasic currently in clinical evaluation in a phase III trial in multiple myeloma (ADMYRE). Presently, the hydrophobic drug plitidepsin is formulated using Cremophor®, an adjuvant associated with unwanted hypersensitivity reactions. In search of alternatives, we developed and tested two nanoparticle-based formulations of plitidepsin,… (More)
To understand the complex nanoscale dehydration process during the lower critical solution temperature (LCST) based inverse phase transition of a class of thermoresponsive biopolymers, diblock elastin-like polypeptides (ELPs) were investigated by spin probing continuous wave electron paramagnetic resonance (CW EPR) spectroscopy. The diblock copolymers… (More)
Two commercial statistical copolymers of ethylene oxide and propylene oxide, Jeffamine® M-2005 (PEO5-st-PPO37) and M-2070 (PEO46-st-PPO13), exhibiting lower critical solution temperature (LCST) in water, were grafted onto the surface of ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) using silanization and amide-bond coupling reactions. The… (More)
Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.
Water-soluble stimuli-responsive AB2 miktoarm star copolymers were prepared by atom transfer radical polymerisation of styrene followed by chain-end modification, polymerisation of either gamma-benzyl-L-glutamate N-carboxyanhydride or tert-butylacrylate and a final step of hydrolysis.