Sávio de Moraes

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The effects of withdrawal from chronic ethanol administration on locomotion and rearing frequencies of rats and mice were studied. Ethanol withdrawal induced a significant increase in animal's activity. In mice a positive correlation was found between locomotion plus rearing frequencies and audiogenic-induced seizures susceptibility 25 hr after ethanol(More)
1. Forced swim (three daily sessions) resulted in an increased plasma corticosterone level and supersensitivity of the isolated rat pacemaker to the chronotropic effect of isoprenaline. 2. Bilateral adrenalectomy, performed 2 days before forced swim, abolished the development of pacemaker supersensitivity to isoprenaline. 3. Administration to rats of the(More)
We studied the role played by postjunctional adrenoceptors in the vasoconstrictor responses of perfused tail arteries of young prehypertensive (4-6 weeks old) and adult (14-16 weeks) spontaneously hypertensive rats (SHR) with norepinephrine (NE), phenylephrine and epinephrine. Age-matched Wistar normotensive rats (WNR) were also used. In tail artery of(More)
1. The effects of swim-induced stress on rat atrial norepinephrine content, plasma corticosterone level and pacemaker sensitivity to catecholamines were studied. 2. Swimming for 50 min reduced the atrial norepinephrine content and induced a long-lasting increase in the plasma corticosterone level. 3. Pacemakers isolated from swim stressed rats showed(More)
Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of the patients may develop regional distant metastases, and lungs and kidneys have been regarded as the most usual sites for implantation. There is, however, little information on the metastatic behavior of this malignancy. We report the first case of patient with(More)
Vasa deferentia isolated from morphine-treated mice were subsensitive (tolerant) to the inhibitory effect of morphine on field stimulation-induced contractions (4.1 fold at the IC50 level) and exhibited supersensitivity to exogenously added noradrenaline. The magnitude of the supersensitivity to noradrenaline was not affected by the absence (2.6 fold) or(More)
1. This article examines the effects of hypoxia on the contractile response of isolated human umbilical artery strips to 5-hydroxytryptamine (5-HT). 2. Hypoxic conditions produce a large increase in the contractile response to 5-HT without a significant alteration of the sensitivity evaluated at the level of the pD2 value. Indomethacin (10 microM) reduced(More)
1. To investigate the possible role of endogenous thromboxane A2 (TXA2) in 5-hydroxytryptamine (5-HT)-induced contraction, human umbilical artery strips were suspended in isolated organ chambers for measurement of isometric force. 2. In endothelium intact strips, arachidonic acid (AA;1 microM) potentiates the contractile response to 5-HT, whereas the(More)