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Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1α (HP1α) with
Background: We showed that nuclear tyrosine phosphorylation is involved in chromatin structural changes. Results: Several tyrosine kinases phosphorylate KAP1 at Tyr-449, Tyr-458, and Tyr-517 in the
Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage*
The results suggest that, upon mimosine treatment, ATM blocks S phase entry in response to ROS, which prevents replication fork stalling-induced DNA damage.
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules
It is suggested that Fyn facilitates mitotic spindle formation through the increase in microtubule polymerization, resulting in the acceleration of M‐phase progression.
Protective role for lipid modifications of Src-family kinases against chromosome missegregation
Results suggest that Src’s membrane anchorage through their lipid modifications from prophase to anaphase plays a protective role against induction of chromosome missegregation.
Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.
The findings, which show that Ct-OATP1B3 mRNA exists in EVs and can be detected in (at least) mouse serum, strengthen the potential use of Ct- oatP1b3 mRNA as a serum-based CRC biomarker.
A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation
It is demonstrated that by tuning mitochondrial metabolism, lncFAO acts as a node of immunometabolic control in macrophages during the resolution and repair phases of inflammation, which is vital for repair and restoration of homeostasis after tissue damage.
Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix*
Protein kinase A anchoring protein 8 (AKAP8/AKAP95), which associates with chromatin and the nuclear matrix, is identified as a nuclear tyrosine-phosphorylated protein, suggesting that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyosine phosphorylation.