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Hemocytes of Ciona intestinalis express multiple genes involved in innate immune host defense.
Ascidians, which are classified as urochordata, appear to employ a primitive system of host defense that is considered to be a prototype of vertebrate innate immunity. We performed a cDNA/EST studyExpand
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Identification and sequence of seventy-nine new transcripts expressed in hemocytes of Ciona intestinalis, three of which may be involved in characteristic cell-cell communication.
Ascidian is a useful experimental animal for studying body planning principles and host defense mechanisms employed by the phylum chordata. Toward this goal, genome and cDNA/EST projects of CionaExpand
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Overexpression of the Runx3 Transcription Factor Increases the Proportion of Mature Thymocytes of the CD8 Single-Positive Lineage1
The Runx family of transcription factors is thought to regulate the differentiation of thymocytes. Runx3 protein is detected mainly in the CD4−8+ subset of T lymphocytes. In the thymus ofExpand
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Identification of transcripts expressed preferentially in hemocytes of Ciona intestinalis that can be used as molecular markers.
The immunity provided by ascidian hemocytes represents one prototype of innate immune function in vertebrates. However, there are currently no molecular markers of ascidian hemocytes. We accumulatedExpand
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Domain analyses of the Runx1 transcription factor responsible for modulating T‐cell receptor‐β/CD4 and interleukin‐4/interferon‐γ expression in CD4+ peripheral T lymphocytes
The Runx1 transcription factor is one of the master regulators of T‐lymphocyte differentiation. There have been several reports trying to assign a domain within the Runx1 protein that is responsibleExpand
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