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To understand global effector mechanisms of CTL therapy, we performed microarray gene expression analysis in a murine model using pmel-1 T-cell receptor (TCR) transgenic T cells as effectors and B16 melanoma cells as targets. In addition to upregulation of genes related to antigen presentation and the MHC class I pathway, and cytotoxic effector molecules,(More)
Matrix metalloproteinases (MMPs) have been reported to be involved in various inflammatory disorders. Previous studies revealed that MMP-2 and MMP-9 might play important roles in the breakdown of the blood-brain barrier (BBB) in the central nervous system (CNS) of patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP).(More)
Alpha-dystroglycan is a cell surface peripheral membrane protein which binds to the extracellular matrix, while beta-dystroglycan is a type I integral membrane protein which anchors alpha-dystroglycan to the cell membrane via the N-terminal extracellular domain. The complex composed of alpha- and beta-dystroglycan is called the dystroglycan complex.(More)
Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory Th1 (mTh1) responses and thereby enhance(More)
Specific cellular immunotherapy for cancer requires efficient generation and expansion of cytotoxic T lymphocytes (CTLs) that recognize tumor-associated antigens. However, it is difficult to isolate and expand functionally active T-cells ex vivo. In this study, we investigated the efficacy of a new method to induce expansion of antigen-specific CTLs for(More)
The dystroglycan (DG) complex, composed of two subunits αDG and βDG, interacts with the sarcoglycan complex to form the dystrophin-glycoprotein complex. αDG is a cell surface peripheral membrane protein which binds to the components of the extracellular matrix, while βDG is a type I integral membrane protein which anchors αDG to the cell membrane via the(More)
Dendritic cell (DC)-based vaccines relying on several distinct methods for antigen loading have been developed for cancer immunotherapy. 1 In this context, it has been shown that Vγ9 γδ T cells activated by zoledronate can link the innate and adaptive arms of the immune system via DCs so to boost the activation of tumor-associated antigen (TAA)-specific CD8(More)
— This paper addresses the system identification and advanced control of a helium (He) liquifier supplying cooling power at liquid helium (LHe) temperatures (-269 • C). To study the dynamic response to heat load variation, a He liquifier simulation model is utilized. The main focus is to regulate the discharge pressure of the compressor station to guarantee(More)
gδ T cells, a small subset of T lymphocytes, are involved in innate immunity. It has been demonstrated that gδ T cells have cytotoxic activities against cells infected with a variety of viruses. However, there is little evidence suggesting a cytotoxic activity of gδ T cells against HTLV-1-infected cells. Therefore, we investigated whether gδ T cells play a(More)
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