Ryszard J. Chetkowski

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We conducted a dose-response study in 23 postmenopausal women to compare the physiologic effects of transdermal estradiol and oral conjugated equine estrogens. The doses studied were 25, 50, 100, and 200 micrograms of transdermal estradiol per 24 hours, and 0.625 and 1.25 mg of oral conjugated estrogens. Transdermal estradiol increased circulating(More)
OBJECTIVE To determine the effect of serum P on endometrial histology in stimulated cycles. DESIGN Prospective clinical study. SETTING Community hospital-based donor oocyte program. PATIENT(S) Fertile young oocyte donors and infertile donor oocyte recipients. INTERVENTION(S) Oocyte donors underwent gonadotropin stimulation after midluteal pituitary(More)
OBJECTIVE To define the recipient-related determinants of outcome with donor eggs. DESIGN Case-control study. SETTING Community hospital-based assisted reproductive technology (ART) program. PATIENT(S) One hundred thirty-four embryo transfers (ETs) in which two recipients were matched to one donor. INTERVENTION(S) Controlled ovarian hyperstimulation(More)
During the first 2 1/2 years of operation of the University of California at Los Angeles in vitro fertilization-embryo transfer program, 47 clinical pregnancies were achieved in 154 laparoscopies for oocyte aspiration (31%). Two of these pregnancies were achieved through transfer of cryopreserved embryos when ongoing pregnancy did not result from embryo(More)
OBJECTIVE To determine the availability of donated cryopreserved embryos. DESIGN Retrospective review. SETTING Community hospital-based IVF-ET program. PATIENTS Eighty-three consecutive infertile couples who had 98 sets of embryos cryopreserved after IVF-ET and GIFT between January 1, 1989 and December 31, 1991. INTERVENTION(S) Cryopreservation of(More)
Late-onset congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a cause of hirsutism in adult women. Its reported frequency of occurrence in hirsute women has varied from 0-30%, but the number of patients studied was small. To establish the incidence of CAH, 83 unselected hirsute women were studied prospectively with a standard ACTH(More)
OBJECTIVE To examine the effect of pituitary suppression and the women's age on embryo viability and uterine receptivity. DESIGN Retrospective analysis of 394 embryo transfers (ET) after in vitro fertilization (IVF). SETTING Community hospital IVF program from 1986 to 1990. PATIENTS Three groups were studied: women less than 40 years with pituitary(More)
In vitro development of 2-cell mouse embryos to the blastocyst stage was used to assess the toxicity of isofluorane, nitrous oxide, fentanyl, and meperidine. Isofluorane at concentrations similar to those employed during human oocyte recovery for IVF significantly inhibited mouse embryo development. Since the other agents were without effect, balanced(More)
A randomized prospective double blind study was performed to assess the ability of a transdermal therapeutic system (TTS) delivering estradiol (E2) to suppress hot flashes (HFs) in symptomatic postmenopausal women. Patients were given placebo or E2 in four doses for a 20-day period, and serum gonadotropin and estrogen levels and the occurrences of HFs were(More)
BACKGROUND Studies carried out over the past 10 years have suggested that hydrosalpinges reduce the pregnancy rate in IVF. Here we report our observations of spontaneous pregnancies in patients who underwent salpingectomy (n = 18) or proximal tubal occlusion (n = 7) following diagnoses of unilateral hydrosalpinges and patent contralateral tubes. METHODS(More)