Ryota Yanase

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(1S,5S,6R,7R)-7-Chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714), a novel cyclic amidine analogue, inhibits human inducible nitric oxide (iNOS) with a K(i) of 1.88 nM and rodent iNOS with similar potency in vitro. ONO-1714 was found to be 10-fold selective for human iNOS over human endothelial NOS (ecNOS). When the inhibitory(More)
Various allyl compounds were tested as anti-HIV reagents. Of all the allyl compounds tested, allyl disulfide (CH2 = CH-CH2-S-S-CH2-CH = CH2), allyl alcohol (CH2 = CH-CH2-OH), and its ester strongly depressed cell proliferation of HIV-1-infected cells. KC50 (50% killing concentration) of the allyl disulfide and the allyl alcohol were 34 microM and 10 microM,(More)
The first total synthesis of (+)-sulfamisterin (AB5366), a naturally occurring alpha-substituted alpha-amino acid derivative possessing a sulfonated hydroxy function, is described. Overman rearrangement of an allylic trichloroacetimidate derived from D-tartrate effectively generated the tetrasubstituted carbon containing a nitrogen substituent. Construction(More)
  • Ryota Yanase
  • Shinrigaku kenkyu : The Japanese journal of…
  • 2001
The present study investigated the effects of the spatial information for cognitive distance in an architectural space. One hundred undergraduate students participated in the experiment, and they were divided into two groups. The control group (CG) was given the pictures of both ends of the routes, and the experimental group (EG) was given some scenes of(More)
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