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LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells
ABSTRACT Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severeExpand
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Autotaxin Overexpression Causes Embryonic Lethality and Vascular Defects
Autotaxin (ATX) is a secretory protein, which converts lysophospholipids to lysophosphatidic acid (LPA), and is essential for embryonic vascular formation. ATX is abundantly detected in variousExpand
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ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation
The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G protein-coupled receptors to mediate both unique and overlapping biological effects, including cell migration, proliferationExpand
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Lysophospholipid Mediators: Their Receptors and Synthetic Pathways
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies ofExpand
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Identification and biochemical characterization of a second zebrafish autotaxin gene
Autotaxin (ATX) is a secreted enzyme that produces a bioactive lysophospholipid, lysophosphatidic acid (LPA). ATX plays a role in vascular and neural development in embryos but its mechanisms remainExpand
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LPP 3 localizes LPA 6 signalling to non-contact site in endothelial cells
Lysophosphatidic acid (LPA) is an emerging angiogenic factor, as knockdown of its producing enzyme, autotaxin and receptors caused severe developmental vascular defects in both mice and fish. InExpand