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Microcavity array system for size-based enrichment of circulating tumor cells from the blood of patients with small-cell lung cancer.
In this study, we present a method for efficient enrichment of small-sized circulating tumor cells (CTCs) such as those found in the blood of small-cell lung cancer (SCLC) patients using aExpand
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Development of the automated circulating tumor cell recovery system with microcavity array.
Circulating tumor cells (CTCs) are well recognized as useful biomarker for cancer diagnosis and potential target of drug discovery for metastatic cancer. Efficient and precise recovery of extremelyExpand
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Manipulation of a Single Circulating Tumor Cell Using Visualization of Hydrogel Encapsulation toward Single-Cell Whole-Genome Amplification.
Genetic characterization of circulating tumor cells (CTCs) could guide the choice of therapies for individual patients and also facilitate the development of new drugs. We previously developed a CTCExpand
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Rapid imaging and detection of circulating tumor cells using a wide-field fluorescence imaging system.
Circulating tumor cells (CTCs) provide potentially accessible in vivo sources of metastatic cancer cells. As such, considerable focus has been placed on analyzing the genetics of single-CTCs. PriorExpand
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High-Throughput Manipulation of Circulating Tumor Cells Using a Multiple Single-Cell Encapsulation System with a Digital Micromirror Device.
Circulating tumor cells (CTCs) are potential precursors of metastatic cancer, and genomic information obtained from CTCs have the potential to provide new insights into the biology of cancerExpand
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Gel-based cell manipulation method for isolation and genotyping of single-adherent cells.
Genetic analysis of single-cells is widely recognized as a powerful tool for understanding cellular heterogeneity and obtaining genetic information from rare populations. Recently, many kinds ofExpand
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Evaluation of cancer cell deformability by microcavity array.
A cell entrapment device consisting of a microcavity array was used to analyze the deformability of MCF-10 human breast epithelial and MCF-7 human breast cancer cell lines by confocal laser scanningExpand
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Towards single-cell genome analysis of circulating tumor cells based on microcavity array
Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients with metastatic cancer. CTCs are well recognized as accessible and valuable biomarkers forExpand
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Performance evaluation of a high‐throughput separation system for circulating tumor cells based on microcavity array
We developed a novel multiple single‐cell encapsulation system equipped with a high magnification lens for high throughput and a more accurate single‐ cell encapsulation. Expand