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• The Quaternary climatic changes resulted in range shifts of species, providing chances for hybridization. However, the genetic signatures of such ancient introgression have rarely been reported. To investigate such signatures, we performed a phylogeographical study on the perennial plant Veratrum album ssp. oxysepalum, which may have hybridized long ago(More)
Cellular FLIP (cFLIP) is a homologue of caspase-8 without protease activity that inhibits the apoptosis signaling initiated by death receptor ligation. We previously reported that a long form of cFLIP (cFLIP-L) inhibits ubiquitylation of beta-catenin and enhances Wnt signaling. Here we show that cFLIP-L impairs the function of the ubiquitin-proteasome(More)
Overexpression of an anti-apoptotic protein cIAP1 caused by its genetic amplification was reported in certain cancers, such as hepatocellular carcinoma, esophageal squamous cell carcinoma, cervical cancer, and lung cancer, which confers resistance to chemotherapy and radiotherapy. Here we report cIAP1 to be selectively down-regulated by a class of small(More)
In the mammalian cell cycle, both CYCLIN A and CYCLIN B are required for entry into mitosis, and their elimination is also essential to complete the process. During mitosis, CYCLIN A and CYCLIN B are ubiquitylated by the anaphase-promoting complex/cyclosome (APC/C) and then subjected to proteasomal degradation. However, CYCLIN A, but not CYCLIN B, begins to(More)
Recently, several efforts to implement and use an unconditionally secure multi-party computation (MPC) scheme have been put into practice. These implementations are passively secure MPC schemes in which an adversary must follow the MPC schemes. Although passively secure MPC schemes are efficient, passive security has the strong restriction concerning the(More)
Veratrum stamineum var. micranthum is a perennial herb listed in the Red Data Book of Japan that is geographically restricted to central Japan. We developed 10 polymorphic microsatellite markers to examine genetic variability in this species. The observed and expected heterozygosities ranged from 0.333–1.000 and 0.370–0.898, respectively. Two of the 10 loci(More)