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1. The biologic activity of androgens is mediated through the formation of a non-covalent androgen receptor (AR)-steroid complex. Casodex and other antiandrogens inhibit formation of this complex and thus negate the role of endogenous steroids in androgen-dependent growth of prostate. 2. Casodex is currently available as a racemic mixture. The goal of this(More)
Glioblastoma Multiforme (GBM) continues to demand improved chemotherapeutic solutions. In order to discover novel chemotherapeutic agents for GBM, we identified novel tetrahydroisoquinoline (THI) analogs as antiglioma agents. The present study reports the design, synthesis and in vitro evaluation of new THI derivatives in four established human glioma cell(More)
Much of the success of Haskell’s Software Transactional Memory (STM) can be attributed to the language’s type system and purity, which together allow transactions to be expressed safely and precisely. By construction, transactions are free from many of the perils that other systems must work hard to avoid. Users do have to work in a constrained environment(More)
At TRANSACT 2014 we described plans and a preliminary implementation for a hybrid TM for the Glasgow Haskell Compiler. Here we give an update on our work and new performance results on a 72-thread Intel Haswell system showing that hardware transactional memory can improve the performance of Haskell TM at realistic scales. We describe our constant space(More)